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《準分子激光角膜屈光術(shù)后皮質(zhì)類固醇性高眼壓臨床相關(guān)因素分析.doc》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、準分子激光角膜屈光術(shù)后皮質(zhì)類固醇性高眼壓臨床相關(guān)因素分析作者：王秀青 翟軍印 賀翔鴿 白繼【摘要】 目的：探討準分子激光角膜屈光術(shù)后皮質(zhì)類固醇性高眼壓的發(fā)生率、臨床相關(guān)因素及預(yù)后。方法：對2005-12/2006-12間行LASIK或LASEK的2060例4060眼滴糖皮質(zhì)激素眼液（1g/L地塞米松及1g/L氟米龍）2～3mo，術(shù)后1wk；1，2，3，6mo及1a觀察眼壓變化，對高眼壓者進行治療，并采用Logistic方法分析高眼壓與年齡、性別、眼別、最大徑線屈光度、最大徑線角膜曲率、角膜切削深度和
2、眼底垂直徑杯/盤比值的相關(guān)性。結(jié)果：有88例143眼發(fā)生了高眼壓，發(fā)生率為3.5%，所有高眼壓患者經(jīng)藥物治療眼壓均降至正常。Logistic回歸分析結(jié)果顯示，眼底杯/盤比值與高眼壓相關(guān)性P值為0.015，OR值為3.071，其他因素P值均大于0.1。眼底垂直徑杯/盤比值大于等于0.4者發(fā)生皮質(zhì)類固醇性高眼壓的幾率是小于0.4者的3.071倍。結(jié)論：準分子激光角膜屈光術(shù)后應(yīng)用糖皮質(zhì)激素眼液可引起部分患者發(fā)生皮質(zhì)類固醇性高眼壓，眼底垂直徑杯/盤比值與皮質(zhì)類固醇性高眼壓有較強相關(guān)性，大于等于0.4是皮質(zhì)類固
3、醇性高眼壓的高危因素，對眼底杯/盤比值大于等于0.4者術(shù)后可酌情減少激素用量和/或加用降眼壓藥物。【關(guān)鍵詞】皮質(zhì)類固醇性高眼壓 準分子激光角膜屈光手術(shù) 杯/盤比值 Clinicalanalysisofcorticosteroid-inducedocularhypertensionafterlaserkeratorefractivesurgeryAbstractAIM:Tostudytheincidence,clinicalrelatedfactorsandtherapeuticeffectsofco
4、rticosteroid-inducedocularhypertensionafterlaserkeratorefractivesurgery(LASIKandLASEK).METHODS:Afollow-upstudyon4060eyesafterlaserkeratorefractivesurgerybetweenDecember2005andDecember2006wasperformed.Corticosteroid(1g/Ldexamethasoneand1g/Lfluoromethalon
5、e)eyedropswereapplied2-3monthspost-operativelyandintraocularpressurewasmeasuredat1week,1,2,3,6and12months,theeyeswithincreaseofintraocularpressureweretreated.Binarylogisticregressionwasusedtoanalyzetherelationshipbetweenocularhypertensionandage,sex,eye,
6、maximumdiopter,maximumcurvature,corneacuttingdepth,andverticalcup/discratio.RESULTS:Corticosteroid-inducedocularhypertensionoccurredin3.5%ofthe4060eyes.Theintraocularpressure(IOP)oftheeyesdroppedtonormallevelinallpatientsafterdrugtreatments.Resultsofbin
7、arylogisticregressionshowedsignificance(Pvalue)betweenocularhypertensionandcup/discratiowas0.015andall5othersexceeded0.1,ORratio:3.071,whichmeanthatincidenceofcorticosteroid-inducedocularhypertensiononpatientswithverticalcup/discratioexceeding0.4wasmore
8、3timesthanthosewithcup/discratiolessthan0.4.CONCLUSION:Topicalapplicationofcorticosteroiddropsmaycausecorticosteroid-inducedhypertensioninsomebodyafterlaserkeratorefractivesurgery.Thereisclosecorrelationbetweencorticosteroid-indu
