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1、新生兒缺氧缺血性腦病的臨床治療(成都市錦江IX:婦幼保健院610000)【摘要】目的:探討新生兒缺氧缺血性腦病的有效治療方法。方法:納入78例缺氧缺血性腦病患兒參與研宄,并將78例患兒平均分成治療組和對(duì)照組,均對(duì)兩組患兒實(shí)施常規(guī)治療,在常規(guī)治療的基礎(chǔ)上予以對(duì)照組患兒胞二磷膽堿沿療,予以沿療組患兒神經(jīng)節(jié)昔脂、冶療。結(jié)果:’冶療組患兒的臨床'冶療總有效率為92.3%,與對(duì)照組患兒的74.4%比較差異明顯(P<0.05),治療前兩組患兒的NBNA評(píng)分(新生兒行為神經(jīng)測(cè)定評(píng)分}、CDCC評(píng)分(中國(guó)兒童發(fā)育量表)比較均無(wú)明顯差異(P>0.05),治療后2周、4周治療組患兒的NB
2、NA評(píng)分均高于對(duì)照組患兒(P<0.05),出生2個(gè)月、3個(gè)月治療組患兒的CDCC評(píng)分明顯高于對(duì)照組患兒(P<0.05)。結(jié)論:在常規(guī)治療的基礎(chǔ)上,應(yīng)用神經(jīng)節(jié)苷脂治療新生兒缺氧缺血性腦病,可有效改善患兒神經(jīng)系統(tǒng)功能,提高患兒臨床治愈率?!娟P(guān)鍵詞】新生兒;缺氧缺血性腦?。坏r經(jīng)節(jié)苷脂;臨床效果【中圖分類(lèi)號(hào)】R2【文獻(xiàn)標(biāo)號(hào)】A【文章編號(hào)】2095-7165(2015)18-05-02Neonatalhypoxic-ischemicencephalopathyclinicaltreatment[Abstract]Objective:Toinvestigatetheeffecti
3、vetreatmentofneonatalhypoxic-ischemicencephalopathy.Methods:Atotalof78casesofchildrenwithhypoxic-ischemicencephalopathyparticipatedinthestudy,and78casesofchildrenweredividedintotreatmentgroupandcontrolgroup,twogroupsofchildrenareontheimplementationofconventionaltherapy,patientsinthecontrolgro
4、uptobetreatedonthebasisofconventionalchildrenciticolinetreatment,betreatedgroupofchildrengangliosidetreatment.Results:Clinicaltreatmentofchildrenwiththerapygroup,thetotaleffectiveratewas92.3%,74.4%comparedwiththecontrolgroupofchildrenwithsignificantdifferences(P<0.05),twogroupsofchildrenof
5、pre-treatmentNBNAscore(neonatalbehavioralneurologicalassessmentscores),CDCCRating(ChineseChildDevelopmentInventory)showednosignificantdifference(P>0.05),aftertreatmentinchildren2weeks,4weekstreatmentgroupsNBNAscoreswerehigherinchildren(P<0.05),wasborntwomonths,children3monthsoftreatment
6、groupwassignificantlyhigherinchildrenCDCCscores(P<0.05).Conclusion:Onthebasisofconventionaltherapy,theapplicationofgangliosidetreatmentofneonatalhypoxic-ischemicencephalopathy,whichcaneffectivelyimprovethefunctionofthenervoussysteminchildren,improvetheclinicalcurerateinchildren.[Keywords]n
7、ewborns;hypoxic-ischemicencephalopathy;gangliosides;clinicaleffect新生兒缺氧缺血性腦病為圍產(chǎn)期新生兒比較常見(jiàn)的腦部病變,主要由窒息缺氧和宮內(nèi)窘迫引起,臨床癥狀表現(xiàn)為嗜睡、神志不清、反應(yīng)遲鈍等,隨著病情的不斷加重可引發(fā)腦性癱瘓、癲癇、腦積水等嚴(yán)重后遺癥,是導(dǎo)致新生兒發(fā)生神經(jīng)系統(tǒng)功能障礙的主要原因,嚴(yán)重影響新生兒健康成長(zhǎng)。早期我國(guó)臨床多采用供氧、控制驚厥、腦水腫等常規(guī)方法對(duì)缺氧缺血性腦病患兒實(shí)施治療,但并未取得顯著治療