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1、KKME---專業(yè)醫(yī)學搜索引擎http://www.kkme.net/血尿酸和脂蛋白-a水平與冠狀動脈病變程度的關系 作者：李屏，熊曉昉作者單位：貴陽醫(yī)學院附院心內科，貴州貴陽550004 【摘要】目的：探討血尿酸(SUA)和脂蛋白-a[Lp(a)]水平與冠狀動脈病變嚴重程度的相關性。方法：224例患者根據(jù)選擇性冠狀動脈造影(CAG)結果分為冠心病組121例，正常對照組103例，再根據(jù)Gensini評分系統(tǒng)將冠心病組分為2組，其中Gensini積分<30分66例為冠心病A組，Gensini積分≥30分55例為冠心病B組;再根據(jù)冠狀動脈病變支數(shù)分為單支病變組46例，雙支病變組4
2、6例，多支病變組29例。分別測定其SUA和Lp(a)水平，并分析二者與冠心病冠脈病變嚴重程度的相關性。結果：冠心病組SUA和Lp(a)水平明顯高于正常對照組(P<0.05)，冠心病B組SUA和Lp(a)的水平明顯高于冠心病A組(P<0.05)，雙支病變組和多支病變組之間比較冠脈病變支數(shù)越多，SUA和Lp(a)水平就越高(P<0.05)，單支病變組與對照組比較SUA和Lp(a)的水平差異無統(tǒng)計學意義(P>0.05)。SUA與Gensini積分相關系數(shù)為0.451，Lp(a)與Gensini積分相關系數(shù)為0.413。結論：動脈粥樣硬化(AS)患者SUA和Lp(a)的水平高低與冠狀動脈
3、病變嚴重程度呈明顯正相關。 【關鍵詞】脂蛋白(A);冠狀動脈疾病;冠狀血管造影術;血尿酸 AResearchontheRelationshipofBloodUricAcidandKKME---專業(yè)醫(yī)學搜索引擎http://www.kkme.net/Lipoprotein-a LevelwiththePathologicalConditionofCoronaryArtery LIPing,XIONGXiaofang (DepartmentofCardiovascularMedicine，TheAffiliatedHospitalofGuiyangMedicalColleg
4、e，Guiyang550004，Guizhou,China) [Abstract]Objective:Toinvestigatetherelationshipofserumuricacid(SUA)andlipoprotion-a(LP-a)withthepathologicalconditionofcoronaryartery.Methods:Accordingtocoronaryangiography,twohundredandtwenty-fourpatientsweredividedintotwogroups:Thecoronaryheartdisease(CHD)gr
5、oup(n=121)andnon-CHDgroup(controlgroup)(n=103).TheCHDgroupwasfurtherdividedintotwosubgroupsaccordingtoaccumulatedpointsofGensiniscoringsystem:patientswithGensiniscore<30wereingroupA(n=66),andthosewithGensiniscore≥30ingroupB(n=55).TheCHDgroupwasalsofurtherdividedintothreesubgroupsaccordingtoth
6、enumberofdiseasedvessels:onediseasedvesselgroup(group1,n=46),twodiseasedvesselgroup(group2,n=46),andthreediseasedvesselgroup(group3,n=29).ThelevelsofSUAandLP-aweremeasured,andtherelationshipofthemwiththepathologicalseverityofcoronaryarterywasanalyzed.Results:ThelevelsofSUAandLP-aingroupCHDwer
7、esignificantlyhigherthanthoseofcontrolgroup(P<0.05).ThelevelsofSUAandLP-ainCHDKKME---專業(yè)醫(yī)學搜索引擎http://www.kkme.net/groupBweresignificantlyhigherthanthoseofgroupA(P<0.05).Aphenomenonwasfoundingroups2and3thatThehigherthelevelsofSUAandLP-awere,the
