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《免疫球蛋白與共刺激分子在冠心病發(fā)病機(jī)制中的作用》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫(kù)。
1、天津醫(yī)科大學(xué)碩士學(xué)位論文AbstractobjectiveToinvestigatefunctionsofimmunoglobulins，CD40／CD40ligandsystemandCD134／CD134ligandsystemonimmunologicmechanismofcoronaryheartdisease(CHD)．Methods42healthymaleadultrabbitsweredividedinto6groupsrandomly．Normalcontrolgroup(N)：fedwithnormalfood．NormalcontrolandCSAg
2、roup(N+CSA、：fedwithnormalfoodandgivenCSA10mg／kg／dfor4weeks．CHDgroup(CHD)：fedwith1．5％cholesteroldietandintervenedwithiliacarteryballooninjuryattheendoffourthweek．CHDandCSAgroup(CHD+CSA)：fedwith1．5％cholesteroldiet．intervenedwithiliacarteryballooninjuryattheendoffourthweekandgivenCSAlOmg／kg／
3、dfor4weeks．Restenosisgroup(RS)：fedwith1．5％cholesteroldiet．intervenedwithiliacarteryballooninjuryattheendsoffourthandeighthweek。RestenosisandCSAgroup(RS+CSA)：fedwith1．5％cholesteroldiet．intervenedwithiliacarteryballooninjuryattheendsoffourthandeighthweekandgivenCSA10mg／kg／dfor4weeks．Allrabb
4、itswerekilledattheendoftwelfthweek．Allrabbitswereweightedatthebeginningandendingofthestudy．Peripheralvenousbloodweretakenbothatthebeginningandendingofthestudytomeasureroutinebloodtests，liverandkidneyfunction，bloodlipids，andimmunoglobulinsincludingIgE，IgM，IgG．Iliacarteriesweretakenoncerabb
5、itswerekilled．Partoftheiliacarterieswereconservedatthetemperatureof-80。C，whichwerethenusedtomeasuremRNAexpressionsofCD40，CD40ligand(CD40L)，CD134andCD134ligand(CD134L)throughreversetranscriptionandreal-timefluorescentquantitativepolymerasechainreactiontechniques．Anotherpartwerepreservedinf
6、ormaldehyde，thenusedforhistologicalobservation(includingneointimalproliferationandvascularremodelingthroughhematoxylinandeosinstaining，andtheratioofpositiveCD40，CD40L，CD134andCD134Lcellsthroughimmunohistochemicalmethods)．DatawereanalyzedthroughSPSSsoftware(version18．0)，P<0．05isofstatistic
7、allysignificantdifference．ResultsUnfortunately1rabbitofRSgroupdiedfrombleedingcausedbyiliacarteryballooninjuryattheendingofeighthweek，SO41rabbitswerefinallyenrolledinthestudy．Therewerenosignificantdifferencesamongthebasaldata．(1)OnlychangesofIll天津醫(yī)科大學(xué)碩士學(xué)位論文highdensi
