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《通心絡(luò)對局灶性腦缺血大鼠微血管新生與其代償作用的實驗-.研究》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫。
1、英文摘要ExperimentalstudyontheinterVentionalefl’ectsof1’0ngxinluoonangiogenesisandcompensatoryfunctionafterfocalcerebral●■lSCnemlaABSTRACTobjective：Inthisstudy，directedbycollateraldiseasetheo拶，usingcraniotomy1igationasideofthemiddlecerebralane巧establishedthemodeloffocalcerebralisc
2、hemia．1bexploreen’ectiVelytherapeutic如nctiononneurologicalrecoVe巧ofischemicstroke，wechoseitsrepresentatiVeprescription：Tongxinluo，andobserveditsimerventionaleffectsonbehaVioralscoring，mo叩h0109yofbraintissue，microVasculardensi吼diameterandvolumesofbloodpermsion，relatedangiogenes
3、isfactorsandtheirexpression．Theresultswouldbehelp如lfor如rtherproVidingexperimentalsupportforscientincvalueofcollateraldiseasetheoWinischemiccerebroVasculardisease．Methods：1Thee位ctsofTongxinluooninf．a(chǎn)rctionareaandneurologicalbehaVioroff．ocalcerebralischemiaratsFocalcerebralische
4、miamodelwasdevelopedwithmaleSDratsofhealthSPFgrade．TheanimalswererandomlydiVidedintosixgroups：theshamgroup，themodelgroup，Tong)【inluohi曲一dose(2．49／l(g。d)黟oup，middle．dose(1．29／kg·d)group，10w-dose(O．69／kg·d)groupandthenimodipine(1Omg／1喝·d)group．Usingcraniotomyligationasideofthemi
5、ddlecerebralarteryestablishedthemodeloffocalcerebralischemia．Shamgroupwasonlypushedasidemeninges，notligationVascular．Allgroupswereirrigated，besidessh鋤groupandmodel鏟．oupweregaveisotonicNachloride．TheneachgroupwasdiVidedintothreetimepoints：3d，7dand14d(n。6)．PosturalI沁nexTest，F(xiàn)ore
6、limbMuscleStrengthTestandBeamWalkingTestwereusedforneur0109icalbehaviorgrading．HEstainingwasusedtodetectthehistomo印hologicalchangesofbraintissueandTTCStainingwasusedto5英文摘要calculatetheproportionofcerebralinf打ction2urea．2TheeffectsofTongxinluoonmicrovasculardensi吼di啪eterandVolu
7、mesofbloodper如sionGroupingandmodelingidem．Microvasculardensityofcerebralcortexischemiaareawastestedthrou曲immunohistochemicalkitat14daRerheartpermsionfixation．MicroVasculardiameter，mo巾hologyandvolumesofplasmapermsionofcerebralmicroVessels，throughfemoralVeinbeingper如sedwithFITC—
8、deXtran，wereanalyzedwimlightmicroscope(40times)at14daRerfocal
