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《通心絡(luò)對(duì)局灶性腦缺血大鼠微血管新生與其代償作用的實(shí)驗(yàn)分析》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、英文摘要ExperimentalstudyontheinterVentionalefl’ectsof1’0ngxinluoonangiogenesisandcompensatoryfunctionafterfocalcerebral●■lSCnemlaABSTRACTobjective：Inthisstudy，directedbycollateraldiseasetheo拶，usingcraniotomy1igationasideofthemiddlecerebralane巧establishedthemodeloffocalce
2、rebralischemia．1bexploreen’ectiVelytherapeutic如nctiononneurologicalrecoVe巧ofischemicstroke，wechoseitsrepresentatiVeprescription：Tongxinluo，andobserveditsimerventionaleffectsonbehaVioralscoring，mo叩h0109yofbraintissue，microVasculardensi吼diameterandvolumesofbloodpermsion
3、，relatedangiogenesisfactorsandtheirexpression．Theresultswouldbehelp如lfor如rtherproVidingexperimentalsupportforscientincvalueofcollateraldiseasetheoWinischemiccerebroVasculardisease．Methods：1Thee位ctsofTongxinluooninf．a(chǎn)rctionareaandneurologicalbehaVioroff．ocalcerebralisc
4、hemiaratsFocalcerebralischemiamodelwasdevelopedwithmaleSDratsofhealthSPFgrade．TheanimalswererandomlydiVidedintosixgroups：theshamgroup，themodelgroup，Tong)【inluohi曲一dose(2．49／l(g。d)黟oup，middle．dose(1．29／kg·d)group，10w-dose(O．69／kg·d)groupandthenimodipine(1Omg／1喝·d)group
5、．Usingcraniotomyligationasideofthemiddlecerebralarteryestablishedthemodeloffocalcerebralischemia．Shamgroupwasonlypushedasidemeninges，notligationVascular．Allgroupswereirrigated，besidessh鋤groupandmodel鏟．oupweregaveisotonicNachloride．TheneachgroupwasdiVidedintothreetimep
6、oints：3d，7dand14d(n。6)．PosturalI沁nexTest，F(xiàn)orelimbMuscleStrengthTestandBeamWalkingTestwereusedforneur0109icalbehaviorgrading．HEstainingwasusedtodetectthehistomo印hologicalchangesofbraintissueandTTCStainingwasusedto5英文摘要calculatetheproportionofcerebralinf打ction2urea．2The
7、effectsofTongxinluoonmicrovasculardensi吼di啪eterandVolumesofbloodper如sionGroupingandmodelingidem．Microvasculardensityofcerebralcortexischemiaareawastestedthrou曲immunohistochemicalkitat14daRerheartpermsionfixation．MicroVasculardiameter，mo巾hologyandvolumesofplasmapermsio
8、nofcerebralmicroVessels，throughfemoralVeinbeingper如sedwithFITC—deXtran，wereanalyzedwimlightmicroscope(40times)at14daRerfocal
