川芎嗪改善tia患者腦血流速度和微栓子數(shù)目的臨床觀察

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1、提要目的：觀察川芎嗪對(duì)短暫性腦缺血發(fā)作患者腦血流速度和微栓子數(shù)目的影響。期望通過(guò)觀察，為川芎嗪治療短暫性腦缺血發(fā)作提供臨床依據(jù)。方法：按照入選標(biāo)準(zhǔn)，隨機(jī)抽取短暫性腦缺血發(fā)作患者60名，隨機(jī)分為基礎(chǔ)治療組（30例）和川芎嗪組（30例），治療前分別行經(jīng)顱多普勒超聲（TCD）和微栓子監(jiān)測(cè)檢查。基礎(chǔ)治療組予阿司匹林腸溶片（拜阿司匹靈）100mgPoQd、氯吡格雷（波立維）75mgPoQd、阿托伐他汀鈣片（立普妥）20mgPoQn、鹽酸氟桂利嗪膠囊（西比靈）5mgPoQn，川芎嗪組在基礎(chǔ)治療組的基礎(chǔ)上加用注射用鹽酸川芎嗪(川青)0.24g入生理鹽水250

2、mlivdripQd治療。4周后再行經(jīng)顱多普勒超聲（TCD）和微栓子監(jiān)測(cè)檢查，并運(yùn)用SPASS17.0統(tǒng)計(jì)分析軟件觀察腦血流速度和微栓子數(shù)目的改變。結(jié)果：統(tǒng)計(jì)分析結(jié)果顯示，治療前川芎嗪組和基礎(chǔ)治療組腦血流速度和微栓子數(shù)目無(wú)明顯差異(P>0.05)，治療后兩組腦血流速度和微栓子數(shù)目比較差異明顯（P<0.05)。結(jié)論：靜脈滴注川芎嗪對(duì)改善短暫性腦缺血發(fā)作患者的腦血流速度和微栓子數(shù)目有顯著療效。關(guān)鍵詞短暫性腦缺血發(fā)作；川芎嗪；經(jīng)顱多普勒超聲；微栓子監(jiān)測(cè)TetramethylpyrazineImproveinPatientswithTIACerebra

3、lBloodFlowVelocityandMicroemboliNumberofClinicalObservationSpeciality:InternalmedicineofTraditionalChineseMedicineAuther:ZhangyongshengTutor:Pro.YoukeAbstractObjective:ToobservetheeffectsofLigustrazineonpatientswithtransientischemicattackofcerebralbloodflowvelocityandmicroem

4、bolinumbereffect.Hopethatthroughobservation,ligustrazineintreatingtransientcerebralischemicattacktoprovideclinicalbasis.Method:accordingtothecriteria,arandomsampleofpatientswithtransientischemicattackof60,wererandomlydividedintotreatmentgroup(30cases)andligustrazinegroup(30c

5、ases),beforetreatmentweretranscranialDoppler(TCD)andmicroembolimonitoringinspection.Thebasisofthetreatmentgroup(toaspirinBayaspirin)100mgPoQd,clopidogrel(Plavix)75mgPoQd,atorvastatin(Lipitor)20mgPoQncalcium,FlunarizineHydrochlorideCapsules(sibelium)5mgPoQn,ligustrazinegroupi

6、nfoundationtreatmentgroupbasedontheuseofinjectionligustrazinehydrochloride(Chuan)0.24g250mlivdripQdtreatmentinsaline.4weeksaftertranscranialDoppler(TCD)andmicroembolimonitoringinspection,andusingSPASS17.0statisticalanalysissoftwareoncerebralbloodflowvelocityandmicroembolinum

7、berchange.Results:statisticalanalysisoftheresultsshows,beforetreatmentandfoundationofLigustrazinegrouptreatmentgroupflowvelocityandcerebralmicroembolinumbernodifference(P>0.05),aftertreatment,twogroupsofcerebralbloodflowvelocityandmicroembolinumberobviouslydifferent(P<0.05).

8、Conclusions:intravenousinfusionofLigustrazineonimprovementoftransientischem