糖腎寶治療早期糖尿病腎病的臨床觀察

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1、提要目的：觀察糖腎寶聯(lián)合纈沙坦膠囊（代文）治療早期糖尿病腎病的療效。對象與方法：1、100例DN患者，隨機分為2組。治療組55例、對照組45例，病程5～15年。2、治療組采用基礎治療方案加纈沙坦膠囊(代文)加糖腎寶；對照組采用基礎治療方案加纈沙坦膠囊（代文），兩組均治療1個月，同時觀察治療前后兩組癥狀改善率及實驗室相關指標。結果：治療組能顯著改善患者癥狀，與對照組比較有顯著性差異（P<0.01或P<0.05）；治療組尿微量白蛋白排泄率、血糖、血脂、尿α1微球蛋白及血液流變學指標治療后均較治療前有顯著改善（P<

2、0.05或P<0.01），與對照組比較有顯著性差異（P<0.05）。結論：糖腎寶聯(lián)合纈沙坦膠囊對早期糖尿病腎病療效明顯優(yōu)于單純西藥治療本病，可明顯改善患者癥狀，降低尿白蛋白排泄率、尿α1微球蛋白,降低總膽固醇及甘油三酯，升高高密度脂蛋白，改善血液流變學，保護腎臟。關鍵詞糖腎寶；早期糖尿病腎病；益氣養(yǎng)陰活血法TheclinicalobservationofTangShenBaoonearlystageofdiabeticnephropathySpeciality:CombinationofTraditional

3、ChineseandWesternMedicineClinicalAuthor:NZhaoNaZhaoTutor:iProfessorLinmaoMunmaoMuAbstractObjective:ToobservethecombinedTangShenBaovalsartancapsules(Diovan)inthepatientswithearlydiabeticnephropathy.CombinationofChinesetraditionalandWesternmedicinetherapyonea

4、rlydiabeticnephropathyindiabeticnephropathyadvantages,safe,effective,convenientprescriptionoftraditionalChinesemedicineandthetreatmentmethod.Method:1.100patientswithDN,wererandomlydividedinto2groups.55casesinthetreatmentgroup,45casesinthecontrolgroup,thecli

5、nicalcourseof5～15years.Two2casesofgeneralinformationbyXtest,nosignificantdifference(P>0.05),comparable.2.basisfortreatment,thetreatmentgroup+valsartancapsules(Diovan)80mgonetimeadaysugarrenaltreasure;thecontrolgroup:basictreatment+valsartancapsules(Diovan)8

6、0mgonetimeaday,NovartisChina,onemonthforaperiod.Statisticalmethods:alldatatodealwithSPSS15.0software.Datatomean+SD(?x+s),measurementdatausingttest,countdatausingX2test,Pvaluelessthan0.05consideredthedifferencewasstatisticallysignificant.Result:comparisonofr

7、esultswithTangShenBaotreatmentgroupsurinaryalbumin,lipidbloodrheology,urineα1microglobulininpatientsbeforeandaftertreatmentwassignificantlylower(P<0.05orP<0.01)；onthebloodglucoseandglycatedhemoglobinhasacertainimprovingeffect.Conclusion:Thecombinationofdise

8、aseandsyndromedifferentiation,TangShenBaocombinedwithvalsartancapsuleintreatingearlydiabeticnephropathymicroalbuminuriahasremarkablecurativeeffectespeciallydecreasingonUAER、urineα1microglobulin、TCandTG