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1、安徽農(nóng)業(yè)科學。JournalofAnhuiAgri.Sci.2011,39(30):18556—18557,18560責任編輯石金友責任校對盧瑤四昧藏木香軟膠囊對環(huán)磷酰胺致小鼠免疫低下模型的影響陳湘宏,童麗,王津慧,翁裕馨,劉燕(青海大學醫(yī)學院,青海西寧810001)摘要[目的]研究四味藏木香軟膠囊對環(huán)磷酰胺致小鼠免疫低下模型免疫功能的影響。[方法]以昆明種小鼠為動物模型,分為空白組、模型組、四味藏木香軟膠囊(大、小劑量)組和陽性藥(鹽酸左旋咪唑片)組,觀察環(huán)磷酰胺致小鼠免疫低下模型腹腔巨噬細胞得吞噬率和吞噬指數(shù),采用溶血
2、素抗體測定法觀察小鼠溶血素抗體生成和藥物對DNFB所致小鼠遲發(fā)型變態(tài)反應(yīng)的影響。[結(jié)果]與模型組相比,四味藏木香軟膠囊能明顯增加小鼠腹腔巨噬細胞的吞噬百分率和吞噬指數(shù);促進小鼠機體溶血素抗體的生成。試驗中遲發(fā)型超敏反應(yīng)的小鼠左右耳重量差異顯著,且高于模型組和對照組,差異顯著,有統(tǒng)計學意義。[結(jié)論]四味藏木香軟膠囊能增強環(huán)磷酰胺所致免疫低下小鼠的免疫功能。關(guān)鍵詞四味藏木香軟膠囊;環(huán)磷酰胺;小鼠免疫抑制模型中圖分類號s567文獻標識碼A文章編號o517—6611(2011)30—18556—02EfectsofFourTast
3、esInulaheleniumISoftCapsuleontheLow-immunityModelofMiceCausedbyCyclophasphamideCHENXiang·hongetal(CollegeofMedicine,QinghaiUniversity,Xining,Qinghai810001)Abstract『obiective]TheaimwastostudyontheefectsoffourtastesInulaheleniumIsoftcapsuleonthelow—immunitymodelofmi
4、cecausedbycycloph0sphamide.[Method]TakingmiceinKunningastheanimalmodel,miceweredividedintoblankgroup,modelgroup,positivemedicinegroup(1evamisolehydrochloridetablets),andfourtastesInulaheleniumIsoftcapsulegroup(highandlowdoses).Thephagocyticrateandphagocyticindexof
5、peritonealmacrophagesinmicelow—immunitymodelcausedbycyclophosphamidewereobserved.Efectsofthemicehe—molysinantibodyformationanddrugsonthemicedelayedhypersensitivitycausedbyDNFBwereanalyzedbythehemolysinantibodymensura—tion.[Result]Comparedwiththemodelgroup,fourtast
6、esInulaheleniumIsoftcapsulecouldsignificantlyenhancethephagocyticrateandphag-ocyticindexofpefitonealmacrophagesinmice,andpromotethehemolysinantibodyformationinmice.Inthetest,themicewithdelayedhyper-sensitivityshowedsignificantdifferencesintheleftandrightearweight.
7、Itwasalsohigherthanthemodelgroupandblankgroup,indicatingsig-nificantdifferencesandhavingstatisticalsignificance.[Conclusion]FourtastesInulaheleniumIsoftcapsulecouldenhancetheimmunefunctionofmicecausedby。ycl0ph0sphamide.KeywordsFourtastesInulaheleniumIsoftcapsule;C
8、yclophosphamide;Micelow—immunitymodel四味藏木香被稱為“瑪努輪王”,是80余種藏成藥的基科學儀器廠。礎(chǔ)處方?,在藏藥中具有重要的地位和作用。藏最早的典1.1.3主要試劑。鹽酸左旋咪唑片,購自于四JJI德元藥業(yè)籍《月王藥診》、《四部醫(yī)典》都有關(guān)于它的記載,距今已有集團有