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1、中藥治療呼吸道合胞病毒(RSV)感染臨床療效觀察專(zhuān)業(yè):中醫(yī)兒科學(xué)研究生:陳永芳導(dǎo)師:林東紅主任醫(yī)師摘要ABSTRACT目的:通過(guò)對(duì)冬春季呼吸道感染患兒進(jìn)行呼吸道合胞病毒(RSV-IgM)常規(guī)檢測(cè),對(duì)呼吸道合胞病毒(RSV)感染患兒分別予中西藥治療,比較其療效,為中藥治療RSV療效提供客觀依據(jù)。方法:嚴(yán)格按照試驗(yàn)病例標(biāo)準(zhǔn)選擇呼吸道合胞病毒(RSV)感染患兒60例,采取簡(jiǎn)單隨機(jī)方法分為治療組30例,對(duì)照組30例。組間一般資料無(wú)顯著差異(p>0.05)。兩組均采用如下治療,利巴韋林50~100mg/次,配成20mg/ml濃度霧化吸入,日二次,療程5天;合并細(xì)菌感染者加用抗感染;毛支患兒加用甲基強(qiáng)的
2、松龍1-2mg/kg?d,靜脈滴注,日1次,用3天。酌情加博利康尼1.25~2.5mg/次,沐舒坦7.5-15mg/次,霧化。治療組在此基礎(chǔ)上予中藥湯劑加減麻杏石甘湯(痰熱壅肺型)或加減銀翹散(風(fēng)熱外襲型)化裁治療,每日1劑,療程5天。比較兩組臨床療效,探討中藥對(duì)RSV感染的療效。結(jié)果:(1)治療組臨床療效明顯優(yōu)于對(duì)照組,其顯效率與對(duì)照組比較有顯著差異(P<0.05)。(2)①治療組發(fā)熱患兒體溫恢復(fù)正常時(shí)間比對(duì)照組短,兩組間比較有極顯著性差異(P<0.01)。②治療組患兒咳嗽、氣喘、肺部體征改善方面優(yōu)于對(duì)照組,兩組比較差異顯著(P<0.05)。結(jié)論:中藥治療RSV感染患兒的臨床療效較為確切,
3、中藥治療確有加速炎癥吸收,緩解癥狀,縮短病程之效,尤其退熱、止咳平喘明顯優(yōu)于西藥治療組。主題詞:呼吸道合胞病毒(RSV)/藥物作用兒童麻杏石甘湯銀翹散-31-ClinicalresearchoftraditionalChinesemedicineintreatinginfantswereinfectedwithrespiratorysyncytialvirusMajor:PediatricsofTCMPostgraduate:chenyongfangTutor:ViceProf.LindonghongABSTRACTObjectives:ThrougharoutineRSVcheckofth
4、eflu-infectedchildreninspringandwinter,wecomparetherespectiveeffectoftreatingtheinfectedchildrenwithtraditionalChineseandwesternmedicine,andthusprovideaobjectiveproofforcuringRSVbytraditionalChinesemedicine.Method:Choose60RSV-infectedinfantsaccordingtotestingthecasestandardstrictly,takethesimpleran
5、dommethodtodivideintotwogroupswithtreatinggroup30andcontrolgroup30.Thegeneraldocumentshavenotbeenshowingthedifference(p>0.05)amongthegroups.Wetreatthetwogroupsasfollowing:useribavirin50-100mg/time,atomizationsucks,twiceaday.Whocombinebacterialinfectionuseadditionalanti-infectiondrugs.bronchiolitisi
6、nfantaddandspendglucocorticoid(methylprednisolone2mg/kg.d,intravenousdrip,onceaday,usefor3days.),Terbutaline1.25-2.5mg/time,chymotrypsin4000u/time,atomizationsuckstwiceadaytogetherwithribavirin,itisacourseoftreatmentin7days.TreatgroupbegivetraditionalChinesemedicinedecoctionplusminusmaxingshigan(ty
7、peofphlegm-heatobstructinginthelung)orplusminusLoniceraeandForsythiaePowder(typeofwindandheatinvasionofcutex),treatonthisbasis.Adoseaday,thebabyisregardlessofthetimeanddosagetotake,finishtakingfractionation