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1、來(lái)曲醴二種劑量促排卵的臨床觀察【摘要】目的比較芳香化酶抑制劑-來(lái)曲哇(letrozole,LE)2種不同劑量的促排卵的臨床療效。方法將68例II型生殖內(nèi)分泌異常的不育婦女隨機(jī)分為2組，其中2.5mg組33例，5.0mg組35例，2.5mg組口服LE2.5mg,5.0mg組口服LE5.0mg,均每天1次，連續(xù)服用5do2組均于月經(jīng)周期的10d開(kāi)始作陰道B超監(jiān)測(cè)，隔天1次最大卵泡平均直徑(MFDX10mm,肌注人絕經(jīng)促性腺激素(HMG)75IU,每天1次，連續(xù)3d后如無(wú)優(yōu)勢(shì)卵泡出現(xiàn)，則肌注HMG150IU,每天1次，至優(yōu)勢(shì)卵泡MFD^18mm時(shí)，肌注人
2、絨毛膜促腺激素(HCG)10000IUo結(jié)果HCG日$15mm卵泡個(gè)數(shù)，5.0mg組多于2.5mg組，卵泡成熟所需天數(shù)5.0mg組少于2.5mg組，2組比較，差異均有統(tǒng)計(jì)學(xué)意義(P<0.01);單用LE優(yōu)勢(shì)卵泡出現(xiàn)率、三線征陽(yáng)性率、HCG日子宮內(nèi)膜平均厚度、HCG日最大卵泡MFD,2組比較，差異均無(wú)統(tǒng)計(jì)學(xué)意義;2.5mg組臨床妊娠率為15.2%(5/33),5.0mg組為17.1%(6/35);2組均未出現(xiàn)卵巢過(guò)度刺激綜合征及卵泡未破黃素綜合征。結(jié)論來(lái)曲I坐用于II型生殖內(nèi)分泌異常的促排卵治療吋，可以先使用2.5mg方案，反應(yīng)不良時(shí)可改用5.0mg
3、o【關(guān)鍵詞】不育不孕；來(lái)曲醴；促排卵ClinicalstudyontheeffectsoftwodosesofLetrozoleonovulationinduetionLIUjuan,LIANGRuining,XUling,eta1.GanzhouMaternityandInfantHea1thHospital,Jiangxi341000,China[Abstract]ObjectiveTocomparetheclinicaleffectoftwodosesof-letrozole(LE)onovulationinduetion.MethodsSi
4、xty-eightinfertiledwomenwithtypeIIabnormalreproductiveendocrinewererandomlydividedintotwogroups,33womenwereinthe2.5mggroupand35womeninthe5.0mggroup.Thewomenintwogroupstook2.5mgor5.0mgletrozoleonceadayfor5days?Beginninginthe10thdayafterthemenstrualperiodbothgroupsreceivedthevag
5、inalultrasonicexaminationoncepertwodays.IfthebiggestfollicleMFD<10mm,thewomenreceivedhumanmenopausalgonadotropin75IUonceadayfor3days?Iftherestillwasn’tanydominantfollicle,thewomen,recievedHMG1501uonceadayuntillthedominantfollicleMFD≥18mm.,Thenthewomenwasgivenhumanchor
6、ionicgonadotropin(HCG)10000IUviaintramuscularinjection.Results5.0mggrouphadmorefollicleswith≥15mmthan2.5mggroupintheHCGdays,whilethedaysforfolliclematurityin5?0mggroupwassignificantlylessthanin2.5mggroup(P〈0.01);NosignificantdifferencewasfoundbetweentwogroupsinLEdominantfol
7、licleapprearancerate,thepositiverateofendmetrialdevelopment,averagethicknessofendometriumintheIICGdays?Thepregnancyratewas15.2%for2.5mggroup,17.1%for5.0mggroup.Bothgroupsdidn’thaveovaryoverstimulationsyndromeandluteinizingunrupturedfolliclesyndrome?ConclusionForthetreatm
8、entoftypeIIabnormalreproductiveendocrinewithletrozole,Itmaybe
