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1、VeterinaryMicrobiology,21(1989)1-81ElsevierSciencePublishersB.V.,Amsterdam--PrintedinTheNetherlandsNaturalInfectionwiththePorcineRespiratoryCoronavirusInducesProtectiveLactogenicImmunityagainstTransmissibleGastroenteritisS.BERNARD1,E.BOTTREAUl,J.M.AYNAUD',P.
2、HAVEeandJ.SZYMANSKYalInstitutNationaldelaRechercheAgronomique,LaboratoiredePathologiePorcine,37380Nouzilly(France)2StateVeterinaryInstitute[orVirusResearch,Lindholm,4771Kalvehave(Denmark)3LaboratoireVgt~rinaireUCAAB,Chierry,02400Chdteau-Thierry(France){Accep
3、tedforpublication24April1989)ABSTRACTBernard,S.,Bottreau,E.,Aynaud,J.M.,Have,P.andSzymansky,J.,1989.Naturalinfectionwiththeporcinerespiratorycoronavirusinducesprotectivelactogenicimmunityagainsttransmis-siblegastroenteritis.Vet.Microbiol.,21:1-8.Ourobjective
4、wastoevaluatethelevelofpassiveprotectionagainsttransmissiblegastroenter-itis(TGE)among57newbornpigletsnursingfromsevenseropositivesowspreviouslynaturallyinfectedwithporcinerespiratorycoronavirus(PRCV).Afterchallengeexposureweobservedmortalityratesof44%forlit
5、tersofsevenPRCV-infectedsows,40%forlittersoffoursowsorallyimmunizedwiththeattenuatedTGEVstrainNouzilly,and91%forlittersofsevenseronegativesusceptiblesows.AblockingELISAwithtwoappropriatemonoclonalantibodiesdistinguishedserologicalresponsesofPRCV-infectedsows
6、fromthoseofTGEV-immunizedsows.TheresultssuggestthatnaturalinfectionofthesowwithPRCVmayinduceadegreeofprotectivelactogenicimmunityagainstTGE.INTRODUCTIONThegutepitheliumofthenewbornpigletisthemaintargetofthetransmis-siblegastroenteritis(TGE)coronavirus(TGEV)w
7、hichisthereforeaspecificenteropathogenicvirus(Haelterman,1972).Thetonsilsandrespiratorytractareconsideredassecondarytargets(Kemenyetal.,1975;KemenyandWoods,1977;Furuuchietal.,1979)andrespiratorydisorderscausedbyTGEVareunknown.Since1984,TGEVseroconversionhasb
8、eenobservedintheswinepopulationofdifferentEuropeancountriesintheabsenceofanyclinicaldis-ease.ThesecountriesincludeBelgium(Pensaertetal.,1986),Denmark(P.Have,personalcommunication,1987),France(Je
