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1、不完全川崎病患兒中腦納利肽(BNP)的變化及臨床意義[摘耍]目的探?對不完全川崎病患兒進行血漿NT-proBNP水平檢測的方法及血漿NT-proBNP水平變化臨床意義。方法隨機選擇2014年3月一2016年3月期間在該院接受治療的不完全川崎病(IKD)患兒共35例作為研究對象,將其作為觀察組,治療后進入疾病恢復(fù)期患兒31例,同時選擇同時期住院治療的40例呼吸道感染患兒作為對照組研究對象。對兩組患兒的外周血白細胞計數(shù)、C■反應(yīng)蛋口、血漿NT-proBNP水平進行測定比較。結(jié)果觀察組患兒外周血白細胞計數(shù)(18.2
2、5±5.42)X109/L、C-反應(yīng)蛋白(80.53±41.86)mg/L和血漿NT-proBNP水平(1370±152.00)ng/L均顯著高于對照組(9.40±4.15)X109/L、(13.53±6.03)mg/L和(413±115.00)ng/L,數(shù)據(jù)比較差異有統(tǒng)計學(xué)意義(P<0.05);觀察組患兒經(jīng)過2周后31例患兒進入疾病恢復(fù)期,其中恢復(fù)期崽兒外周血口細胞計數(shù)(17.53±6.25)X109/L、C■反應(yīng)蛋白(70.52±35.63)mg/L和血漿NT-proBNP水平(1368±147.00)n
3、g/L均顯著低于治療前(9.53±2.93)X109/L、(8.53±2.76)mg/L和(501±102.00)ng/L,數(shù)據(jù)比較差異有統(tǒng)計學(xué)意義(P<0.05)o結(jié)論與呼吸道感染患兒相比,不完全川崎病患兒的外周血口細胞計數(shù)、C■反應(yīng)蛋口及血漿NT-proBNP水平均顯著較高,因此早期檢測血漿NT?proBNP水平值利于不完全川崎病的診斷,實現(xiàn)早期診斷早日治療。[關(guān)鍵詞]不完全川崎?。幌Σ分苎准毎?;C?反應(yīng)蛋白;血漿NT-proBNP水平1中圖分類號]R722[文獻標(biāo)識碼]A[文章編號]1674-0742
4、(2017)04(a)-0043-03ChangesofBrainNatriureticPeptideofChildrenwithIncompleteKawasakiDiseaseandClinicalSignificanceWUMing,XUZhi-xiang,CHENMeiDepartmentofPediatrics,XiamenThirdHospitalAffiliatedtoFujianUniversityofTraditionalChineseMedicine,Xiamen,FujianProvin
5、ce,361100China[Abstract]ObjectiveTostudythetestmethodofplasmaNT-proBNPlevelofchildrenwithincompletekawasakidiseaseandclinicalsignificanceofchangesofplasmaNT-proBNPlevel.Methods35casesofchildrenwithincompletekawasakidiseasetreatedinourhospitalfromMarch2014to
6、March2016wereselectedastheobservationgroup,31casesofchildrenenteredintothediseaserecoverystageaftertreatment,atthesametime,40casesofchildrenwithrespiratorytractinfectionatthesameperiodwereselectedasthecontrolgroup,andtheperipheralbloodleucocytecount,C?react
7、iveproteinandplasmaNT-proBNPlevelweremeasuredandcompared?ResultsTheperipheralbloodleucocytecount,C?reactiveproteinandplasmaNT-proBNPlevelintheobservationgroupwereobviouslyhigherthanthoseinthecontrolgroup,[(18.25±5.42)X109/L,(80.53±41.86)mg/L,(1370±152.00)ng
8、/Lvs(9.40±4.15)X109/L>(13.53±6.03)mg/L,(413±115.00)ng/L],andthedifferencesbetweengroupswerestatisticallysignificant(P<0.05),after2-week,31casesofchildrenenteredintothediseaserecoverystage,andtheperiphe