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1、J.Vet.Med.B37,177-180(1990)01990PaulPareyScientificPublishers,BerlinandHamburgISSN0931-1793MinisteredeI'Agriculture,DirectionGPnPraledeI'Alimentation,StationdePathologiePorcine,Ploufragan,FranceDisordersInducedbytheExperimentalInfectionofPigswiththePorcineRespiratoryCoronavirus(P.R
2、.C.V.)P.VANNIERAddressofauthor:MinisteredeI'Agriculture,DirectionGCneraledeI'Alimentation,StationdePathologiePorcine,BP9,22440Ploufragan,FranceWith2tables(ReceivedforpublicationJuly31,1989)SummaryFivecolostrumdeprivedhysterectomy-derivedpigletswereinoculatedbytheintratrachealroutew
3、ithaPorcineRespiratoryCoronavirus(PRCV).Theclinicaleffectsandgrowthperformanceswerecomparedwiththosein5similarpigletswhichwereinoculatedwithMinimumEagleMediumonly.Atransienthyperthermia,mildtoseveredyspnoea,polypnoeaandanobviouscessationofgrowthwererecordedoninfectedpigsonlywhereas
4、thecontrolgroupdidnotshowanyadversereactionafterinoculation.Thereasonsforthevariabilityofeffectsofexperimentalinfectionobservedinprevioustrials,arediscussed.IntroductionAporcinerespiratory,nonentericcoronavirus(PRCV)relatedtoTransmissibleGastroenteritisvirus(TGE)hasbeenisolatedindi
5、fferentcountriesofEuropesince1986(1,2,8).IthasbecomeverywidespreadamongtheswinepopulationsinBelgium,Denmark(4),France,Great-BritainandotherEuropeancountriesbutitspathogenicityhasnotbeenwelldefined.Noparticularclinicalsignwasobservedafteranexperimentalinfection,bytheoronasalroute,in
6、toyoungpiglets(8).However,mildrespiratorydisordersinfatteningpigshavebeenassociatedwiththenaturalinfectiononthefield(3,5).Intratrachealinoculationhasbeenusedwiththepiginfluenzaviruses(6)andwithPRCV(2).ThispaperdescribesfurtherexperimentalinfectionsofPRCVusingintratrachealinoculatio
7、n.MaterialandMethodsPigsTenBelgianLandracexPietrainspecificpathogenfreepigsobtainedbyhysterectomyweredividedinto2groups,at90days-of-age(averageweight38kg).ThefirstgroupoffivepigswasinfectedwithaPRCVstrain.Theothergroupfromthesameorigin,wasinoculatedinsimilarconditionsbutwithMinimum
8、EagleMedium(MEM)only.Eachg
