資源描述：
《sd大鼠生長發(fā)育期心臟結(jié)構(gòu)及功能的超聲心動圖評價》由會員上傳分享，免費在線閱讀，更多相關內(nèi)容在行業(yè)資料-天天文庫。
1、維普資訊http://www.cqvip.com12MolecularCardiologyofChina，F(xiàn)ebruary2008，Vo1．8No．1(SerialNo．38．基礎研究．SD大鼠生長發(fā)育期心臟結(jié)構(gòu)及功能的超聲心動圖評價蓋迎利徐明白燕呂志珍張幼怡李昭屏【摘要】目的應用高頻超聲儀動態(tài)觀測SD雄性大鼠生長發(fā)育階段心臟結(jié)構(gòu)和功能變化規(guī)律，為發(fā)育期實驗大鼠動物模型制備及功能評價提供依據(jù)。方法利用小動物超聲儀連續(xù)觀測sD雄性大鼠出生后1—9周左心室結(jié)構(gòu)及功能的動態(tài)變化。結(jié)果(1)M超檢測結(jié)果顯示左室壁厚度及左室內(nèi)徑隨生長發(fā)育而增加，超聲評估左心室重量與解剖
2、稱重結(jié)果高度相關(r=0．9326，P<0．0001)；(2)左室短軸縮短率(FS％)在發(fā)育期無顯著變化；(3)脈沖多普勒測定舒張早期峰值血流速度(E峰)與舒張晚期峰值血流速度(A峰)之比(E／A)>1，在發(fā)育過程中無顯著性變化；(4)組織多普勒檢測提示：左室后壁心肌的舒張早期(Em)、舒張晚期(Am)及收縮期(Sm)運動速度出生后1—6周逐漸增加，6周時達平臺期。結(jié)論高頻小動物超聲儀經(jīng)胸超聲心動圖所檢測的心臟結(jié)構(gòu)能準確地反映大鼠心臟生長發(fā)育變化趨勢；心臟整體收縮及舒張功能在出生后1周即達穩(wěn)定狀態(tài)；組織多普勒檢測左室后壁心肌縱軸運動在出生后逐漸成熟完善，于6周
3、達到穩(wěn)定狀態(tài)?！娟P鍵詞】心臟；生長發(fā)育；超聲心動圖；大鼠HighFrequencyUltrasoundAssessmentofDevelopmentalChangesofVentricularStructureandFunctioninSDRatGAIYing—i，XUMing2，BAIYan2，￡UZhi—zhen，ZhangYou—yi2，LIZhao·ping“．JDepartmentofCardiology，ThirdHospitalofBering100083，China．2InstituteofVascularMedi—cine，PekingUni
4、versityThirdHospitalandKeyLaboratoryofMolecularCardiovascularSciences，MinistryofEducation，Beijing100083，ChinaCorrespondentauthor．L1Zhao-pingE—mail：lizhao-ping@sohu．corn【Abstract】0bjectiveToassessthedevelopmentalchangesofleftventricularstructureandfunctioninmaleSDratswi山ahighfrequenc
5、yultrasoundsystemandtoprovideevidenceforpreparationofratsmodelandfunctionalevaluation．MethodsUsingultrasonicinstrumentforsmallanimalsconsecutivelytoobserveleftventricularstructureandfunctionofmaleSDratsagedfrom1to9weeks．Results(1)M·modedetec·tionshowedthatleftventricularwallthicknes
6、sandleftventricularinsidediameterincreasedwith晤“g，U1·trasoundassessmentofleftventricularmassshowedahi．ghcorrelationwithanatomicalresults(r=0．9326，尸<0．0001)，(2)Therewasnosignificantchangeinleftventficularfractionalshortening(FS％)duringdevelopmentalperiod．(3)Ventficularfillingwasquant
7、ifiedasratioofearlypeakvelocity(Ewave)toatri-alpeakflowvelocity(Awave)，Inthecourseofdevelopment，E／Aratioishigherthan1，withnosignifi·cantchange．(4)TissueDopplerimagingwasappliedtomeasuremyocardialtissuevelocities：LVposteriorwallearlydiastolic(Em)，latediastolic(Am)andsystolic(Sm)myoca
8、rdialtissuevelociti
