不同標(biāo)本腫瘤標(biāo)志物聯(lián)合檢測對(duì)肺癌的診斷價(jià)值

不同標(biāo)本腫瘤標(biāo)志物聯(lián)合檢測對(duì)肺癌的診斷價(jià)值

ID:5418713

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時(shí)間:2017-12-10

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1、·1838·劉大鷹,等不同標(biāo)本腫瘤標(biāo)志物聯(lián)合檢測對(duì)肺癌的診斷價(jià)值不同標(biāo)本腫瘤標(biāo)志物聯(lián)合檢測對(duì)肺癌的診斷價(jià)值1122劉大鷹,胡灼君,農(nóng)天雷,林敏Diagnosticvalueofcombinedtumormarkersassaysindifferentsamplespatientswithlungcancer1122LIUDaying,HUZhuojun,NONGTianlei,LINMin12DepartmentofRespiration;DepartmentofNuclearMedicine,LiutieCentralHospitalofLiuzh

2、ouCity,GuangxiLiuzhou545007,China.【Abstract】Objective:Toevaluatetheclinicalsignificanceofassayingcarcino-embryonicantigen(CEA),car-bohydrateantigens(CAl25andCAl9-9)andCytokeratin19fragment(CYFRA21-1)inserum,sputum,broncho-alveolarlavagefluid(BALF)andpleuraleffusionofpatientswit

3、hlungcancer.Methods:Usingthemethodofche-mi-luminescentenzymeimmunoassaywithacommerciallyavailableenzymeimmunoassaykit,52caseswithlungcancerand46caseswithbenignlungdiseasesunderwentassayofCEA,CA125,CA199andCYFRA21-1inserum,sputum,BALFandpleuraleffusion.Results:Ofthe52caseswithlu

4、ngcancer,thepositivepercentagesofcombinationassaysofCEA,CA125,CA199andCYFRA21-1wereasfollows:69.2%inserum,90.4%insputum,88.5%inBALFand82.1%inpleuraleffusion,respectively;Butthepositivepercentagesofthosewithbenignlungdiseaseswere19.6%,26.1%、23.9%,21.7%,respectively.Thepositivepe

5、rcentagesofcombinationofthesetumormarkersassaysinpatientswithlungcancerwassignificantlyhigherthaninthosewithnonmalignantrespiratorydiseases(P<0.05).Amongthe52patientswithlungcancer,thediagnosticsensitivityofcombinationofthesetumormarkersassaysinsputumorBALFwassignificantlyhighe

6、rthanthoseinserum(P=0.01;P=0.02).Comparedwiththesingleser-umsamplesthatthesetumormarkersweremeasured,thecombinationof2or3ofthesesamplescouldimprovethesensitivityandaccuratevalueinthediagnosisoflungcancer(P<0.05).Conclusion:ToassayCEA,CA125,CA199andCYFRA21-1inserum,sputum,BALFan

7、dpleuraleffusionwasavaluableaidindiagnosisoflungcancer,andcomparedwiththesingleserumsamplethatthesetumormarkersweremeasured,thecombinationof2or3ofthesesamplescouldimprovesensitivityandaccuratevalueinthediagnosisoflungcancer.【Keywords】lungneoplasm;tumormarkers;serum;sputum;bronc

8、hoalveolarlavagefluid;pleuraleffusion;diagnosisModernO

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