資源描述：
《乳腺實(shí)性乳頭狀癌臨床病理學(xué)特征_楊苗苗》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、臨床與實(shí)驗(yàn)病理學(xué)雜志JClinExpPathol2014May;30(5)·491·網(wǎng)絡(luò)出版時(shí)間:2014－5－2013:28網(wǎng)絡(luò)出版地址:http://www．cnki．net/kcms/doi/10．13315/j．cnki．cjcep．2014．05．005．html乳腺實(shí)性乳頭狀癌臨床病理學(xué)特征1，21，31楊苗苗，翁海燕，孟剛摘要:目的探討乳腺實(shí)性乳頭狀癌的臨床病理學(xué)特征。方法收集9例乳腺實(shí)性乳頭狀癌，行HE及免疫組化染色，根據(jù)WHO(2012)乳腺腫瘤標(biāo)準(zhǔn)進(jìn)行分類。結(jié)果9例乳腺實(shí)性乳頭狀癌中原位實(shí)性乳頭狀癌7例、浸潤(rùn)性實(shí)性乳頭狀癌2例。腫瘤細(xì)胞呈多結(jié)節(jié)狀生長(zhǎng)，結(jié)節(jié)呈圓形、類圓形，
2、邊緣光滑，可見神經(jīng)及脂肪組織內(nèi)浸潤(rùn)。結(jié)節(jié)內(nèi)瘤細(xì)胞常見假菊形團(tuán)及細(xì)胞核圍繞脈管軸心呈柵欄狀排列，7例見較明顯黏液產(chǎn)生。9例癌組織巢內(nèi)細(xì)胞CK8、EＲ均彌漫陽性，巢周及巢內(nèi)肌上皮SMA、p63、CD10均陰性。8例Syn陽性，3例CgA陽性。2例浸潤(rùn)性實(shí)性乳頭狀癌:浸潤(rùn)成分類似浸潤(rùn)性導(dǎo)管癌，但細(xì)胞形態(tài)類似原位癌，且免疫組化標(biāo)記Syn陽性。結(jié)論乳腺實(shí)性乳頭狀癌呈結(jié)節(jié)狀生長(zhǎng)，可見結(jié)節(jié)浸潤(rùn)神經(jīng)及脂肪組織內(nèi)，癌巢周圍肌上皮SMA、p63、CD10均陰性。乳腺實(shí)性乳頭狀癌可能是呈推擠性生長(zhǎng)的浸潤(rùn)性癌。關(guān)鍵詞:乳腺腫瘤;實(shí)性乳頭狀癌;病理學(xué)特征;免疫組織化學(xué)中圖分類號(hào):Ｒ737．9文獻(xiàn)標(biāo)志碼:A文章編號(hào):1
3、001－7399(2014)05－0491－04doi:10．13315/j．cnki．cjcep．2014．05．005Pathologicalcharacteristicsofsolidpapillarycarcinomasofthebreast1，21YANGMiao-miao，WENGHai-yan-1，3，MENGGang12(DepartmentofPathology，AnhuiMedicalUniversity，Hefei230032，China;DepartmentofPathology，AnhuiNo．2ProvincePeo-3ple’sHospital，Hefei230
4、041，China;DepartmentofPathology，AnhuiProvincialHospital，Hefei230001)Abstrast:PurposeToinvestigatetheclinicalmanifestation，morphologiccharacteristicsandimmunophenotypicfeaturesofsolidpa-pillarycarcinomas(SPC)ofbreast．MethodsAccordingtocriterionofWHO(2012)，9casesofSPCofbreastwereselectedandobservedwi
5、thhematoxylineosinstainingandimmunohistochemistry．Ｒesults9casesofSPCwerediagnosedincluding7casesofSPCinsituand2casesofinvasiveSPC．Microscopically，thesetumorsappearedasmultiplenodules．Nodulesdisplayedwell-definedpush-ingbordersandinvadedfattissueandnerve．Nuclearpalisadingaroundthestromalcoresandpseu
6、dorosetteformationaroundcapillaryvesselswerealsocommonfeatures．Extracellularmucinproductioncouldalsobepresentin7cases．AllcaseswerepositiveforEＲandCK8，negativeforSMA，p63，CD10．8caseswerepositiveforSyn．3caseswerepositiveforCgA．2caseswereassociatedwithinva-sivecarcinoma．Theinvasivecomponenthadaneuroend
7、ocrine-likepatternandwasmorphologicallysimilartotheadjacentSPC．Con-clusionSPCmaydisplaynodular，well-definedpushingborderandinvadefattissueandnerve．Theabsenceofmyoepithelialcellsattheperipheryofthetumoriscon
