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1、臨床與實驗病理學雜志JClinExpPathol2014May;30(5)·491·網(wǎng)絡出版時間:2014－5－2013:28網(wǎng)絡出版地址:http://www．cnki．net/kcms/doi/10．13315/j．cnki．cjcep．2014．05．005．html乳腺實性乳頭狀癌臨床病理學特征1，21，31楊苗苗，翁海燕，孟剛摘要:目的探討乳腺實性乳頭狀癌的臨床病理學特征。方法收集9例乳腺實性乳頭狀癌，行HE及免疫組化染色，根據(jù)WHO(2012)乳腺腫瘤標準進行分類。結(jié)果9例乳腺實性乳頭狀癌中原位實性乳頭狀癌7例、浸潤性實性乳頭狀癌2例。腫瘤細胞呈多結(jié)節(jié)狀生長，結(jié)節(jié)呈圓形、類圓形，
2、邊緣光滑，可見神經(jīng)及脂肪組織內(nèi)浸潤。結(jié)節(jié)內(nèi)瘤細胞常見假菊形團及細胞核圍繞脈管軸心呈柵欄狀排列，7例見較明顯黏液產(chǎn)生。9例癌組織巢內(nèi)細胞CK8、EＲ均彌漫陽性，巢周及巢內(nèi)肌上皮SMA、p63、CD10均陰性。8例Syn陽性，3例CgA陽性。2例浸潤性實性乳頭狀癌:浸潤成分類似浸潤性導管癌，但細胞形態(tài)類似原位癌，且免疫組化標記Syn陽性。結(jié)論乳腺實性乳頭狀癌呈結(jié)節(jié)狀生長，可見結(jié)節(jié)浸潤神經(jīng)及脂肪組織內(nèi)，癌巢周圍肌上皮SMA、p63、CD10均陰性。乳腺實性乳頭狀癌可能是呈推擠性生長的浸潤性癌。關(guān)鍵詞:乳腺腫瘤;實性乳頭狀癌;病理學特征;免疫組織化學中圖分類號:Ｒ737．9文獻標志碼:A文章編號:1
3、001－7399(2014)05－0491－04doi:10．13315/j．cnki．cjcep．2014．05．005Pathologicalcharacteristicsofsolidpapillarycarcinomasofthebreast1，21YANGMiao-miao，WENGHai-yan-1，3，MENGGang12(DepartmentofPathology，AnhuiMedicalUniversity，Hefei230032，China;DepartmentofPathology，AnhuiNo．2ProvincePeo-3ple’sHospital，Hefei230
4、041，China;DepartmentofPathology，AnhuiProvincialHospital，Hefei230001)Abstrast:PurposeToinvestigatetheclinicalmanifestation，morphologiccharacteristicsandimmunophenotypicfeaturesofsolidpa-pillarycarcinomas(SPC)ofbreast．MethodsAccordingtocriterionofWHO(2012)，9casesofSPCofbreastwereselectedandobservedwi
5、thhematoxylineosinstainingandimmunohistochemistry．Ｒesults9casesofSPCwerediagnosedincluding7casesofSPCinsituand2casesofinvasiveSPC．Microscopically，thesetumorsappearedasmultiplenodules．Nodulesdisplayedwell-definedpush-ingbordersandinvadedfattissueandnerve．Nuclearpalisadingaroundthestromalcoresandpseu
6、dorosetteformationaroundcapillaryvesselswerealsocommonfeatures．Extracellularmucinproductioncouldalsobepresentin7cases．AllcaseswerepositiveforEＲandCK8，negativeforSMA，p63，CD10．8caseswerepositiveforSyn．3caseswerepositiveforCgA．2caseswereassociatedwithinva-sivecarcinoma．Theinvasivecomponenthadaneuroend
7、ocrine-likepatternandwasmorphologicallysimilartotheadjacentSPC．Con-clusionSPCmaydisplaynodular，well-definedpushingborderandinvadefattissueandnerve．Theabsenceofmyoepithelialcellsattheperipheryofthetumoriscon
