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《鹽酸伐昔洛韋分散片聯(lián)合普瑞巴林治療帶狀皰疹的臨床療效觀(guān)察》由會(huì)員上傳分享,免費(fèi)在線(xiàn)閱讀,更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。
1、鹽酸伐昔洛韋分散片聯(lián)合普瑞巴林治療帶狀皰疹的臨床療效觀(guān)察胡小龍鄧列華(通訊作者)溫淑勛侯靜李詩(shī)娜(暨南大學(xué)附屬第一醫(yī)院皮膚科廣東廣州510630)【摘要】R的:觀(guān)察鹽酸伐昔洛韋分散片聯(lián)合普瑞巴林治療帶狀皰疹的臨床療效。方法:選擇我院2014年10月至2015年10月43例帶狀皰疹患者,隨機(jī)分成治療組和對(duì)照組,治療組用鹽酸伐昔洛韋分散片聯(lián)合普瑞巴林治療,對(duì)照組用鹽酸伐昔洛韋分散片治療,均用藥四周。觀(guān)察患者皮損變化及神經(jīng)痛減輕程度。結(jié)果:治療組患者皮損停止發(fā)展,水皰干涸、結(jié)痂與對(duì)照組無(wú)統(tǒng)計(jì)學(xué)差異(P>0.05),但祌
2、經(jīng)痛減輕程度以及預(yù)防活遺祌經(jīng)痛較對(duì)照組好,有統(tǒng)計(jì)學(xué)差異(P<0.05),兩組患者不良反應(yīng)無(wú)差異(P>0.05)。結(jié)論:鹽酸伐昔洛韋分散片聯(lián)合普瑞巴林治療帶狀皰疹具有較明顯的臨床療效,尤其對(duì)帶狀皰疹祌經(jīng)痛的治療及后遺神經(jīng)痛的預(yù)防比單用鹽酸伐昔洛韋分散片臨床療效更明顯?!娟P(guān)鍵詞】鹽酸伐昔洛韋;普瑞巴林;帶狀皰疹;帶狀皰疹后遺神經(jīng)痛【中圖分類(lèi)號(hào)】R751.05【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1007-8231(2015)20-0104-02Valaciclovirhydrochloridedispersibletab
3、letscombinedwithPregabalinintreatingclinicalobservationofHerpesZoster[Abstract]ObjectiveToobservetheclinicalefficacyofvalaciclovirhydrochloridedispersibletabletscombinedwithpregabalintreatmentofherpeszoster.Methods43patientswithherpeszosterinourhospitalfromOctob
4、er2014toOctober2015wereselected,dividedintotreatmentandcontrolgroupsrandomly.Useofvalaciclovirhydrochloridedispersibletabletsinthetreatmentgroupcombinedwithpregabalinintreating,thecontrolgroupjustusevalaciclovirhydrochloridedispersibletablets,treated4weeks.Obser
5、vedchangesintheskinlesionsofpatientswithneuropathicpainrelieffromthedegree.ResultsTheskinlesionsofpatientsinthetreatmentgrouptostopthedevelopment,blistersdryandscabbynostatisticaldifferenceswiththecontrolgroup(P>0.05),buttreatmentneuropathicpainalleviatingand
6、preventingpostherpeticneuralgia,betterthanthecontrolgroup(P<0.05),andnodifferenceinadversereactions(P>0.05).ConclusionValaciclovirhydrochloridedispersibletabletsintreatingHerpesZosterwithpregabalincombinedwithgoodeffect,especiallyonherpeszosterneuralgiawit
7、htreatmentandpreventionofpostherpeticneuralgiahasasignificantadvantage.【Keywords]Valaciclovirhydrochloridedispersibletablets;Pregabalin;HerpesZoster;HerpesZosterneuralgia帶狀皰疹是由水痘一帶狀皰疹病毒引起的皮膚病。主要表現(xiàn)沿單側(cè)周?chē)窠?jīng)分布的簇集性小水皰,伴冇明顯的神經(jīng)痛,帶狀皰疹后遺神經(jīng)痛是最常見(jiàn)的并發(fā)癥之-。本文通過(guò)觀(guān)察鹽酸伐昔洛韋聯(lián)合樂(lè)瑞卡治療帶
8、狀皰疹的臨床療效來(lái)評(píng)估聯(lián)合用藥對(duì)帶狀皰疹神經(jīng)痛的治療及帶狀皰疹后遺神經(jīng)痛的預(yù)防作用。1.資料和方法:1.1研究對(duì)象我院皮膚科門(mén)診帶狀皰疹患者43例為研究對(duì)象,均符合《皮膚性病學(xué)》[1]中的相關(guān)診斷標(biāo)準(zhǔn)。入選標(biāo)準(zhǔn):(1)明確病史符合帶狀皰疹診斷;(2)就診前未服用或外用藥物,iL發(fā)病不超過(guò)6天;(3)良好的醫(yī)從性。排除標(biāo)準(zhǔn)(1)合并