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1、J圖11山^^因散析2018-03-2712:00:30中國現(xiàn)代醫(yī)生2018年3期周芳許君賈黎紅周杰林張曉曉楊明[摘要]目的探討川崎病(KD)合并冠狀動脈病變的危險因素。方法回顧性分析2014年1月?2016年12月木院169例KD住院患兒的臨床資料;將169例KD分為A、B兩組,其屮A組為KD合并冠狀動脈病變,B組為KD不伴冠狀動脈病變;采用獨立樣本t檢驗分析兩組年齡、發(fā)熱天數(shù)、白細胞數(shù)、超敏C反應蛋0、血沉、血小板數(shù)、血清0蛋白、血鈉、D二聚體與KD冠狀動脈病變的關(guān)系;同時采用ROC曲線分析血淸0蛋白、血鈉、D二聚體預測冠
2、狀動脈病變的效能。結(jié)果KD冠狀動脈病變發(fā)生率為36.69%。A、B組患兒血淸白蛋白、血鈉、D二聚體的差異有統(tǒng)計學意義(P<0.05)。ROC曲線分析顯示血清白蛋白、血鈉、D二聚體曲線下而積分別為0.383、0.353和0.715。血淸白蛋白<35g/L、血鈉<135mmol/L、D二聚體>0.92mg/L是KD合并冠狀動脈病變的危險因素。結(jié)論KD的主耍危害是冠狀動脈病變;血清白蛋0<35g/L、血鈉<135mmol/L、D二聚體>0.92mg/L足KD合并冠狀動脈病變的危險因索。[關(guān)鍵詞]川崎??;冠狀動脈病變;危險因素;D二聚
3、體[屮圖分類號]R725.4[文獻標識碼]B[義章編號]1673-9了01(2018)03-0056-04AnalysisontheriskfactorsofcoronaryarterydiseaseinchildrenwithKawasakidiseaseZHOUFanglXUJun2JIALihonglZHOUJielin2ZHANGXiaoxiao2YANGMing21.DepartmentofNephrology,HangzhouChildren'sHospital,Hangzhou310014,China;2.Dep
4、artmentofNeurology,HangzhouChildren'sHospital,Hangzhou310014,China[Abstract]ObjectiveToinvestigatetheriskfactorsofKawasakidisease(KD)complicatedwithcoronaryarterydisease.MethodsTheclinicaldataof169childrenwithKDwhowerehospitalizedinourhospitalfromJanuary2014toDecemb
5、er2016wereretrospectivelyanalyzed;the169casesofKDweredividedintotwogroups:groupAandgroupB.GroupAwasKDcomplicatedwithcoronaryarterydisease,andgroupBwasKDwithoutcoronaryarterydisease:therelationshipbetweenage,feverdays,whitebloodcellcount,highsensitivityC-reactiveprot
6、ein,erythrocytesedimentationrate,plateletcount,serumalbumin,serumsodium,DdimerandKDcomplicatedwithcoronaryarterydiseasewereanalyzedbyindependentsamplettest:atthesametime,ROCcurvewasusedtoanalyzetheefficacyofserumalbumin,serumsodiumandDdimerinpredictingcoronaryartery
7、disease.ResultsTheincidencerateofKDcoronaryarterydiseasewas36.69%.Thedifferencesofthelevelsofserumalbumin,serumsodiumandDdimerinchildreningroupAandBwerestatisticallysignificant(P<0.05).ROCcurveanalysisshowedthattheareaunderthecurveofserumalbumin,serumsodiumandDdimer
8、was0.383,0.333and0.715,respectively.Serumalbumin<35g/L,serumsodium<135mmol/L,Ddimer>0.92mg/LweretheriskfactorsofKDcomplicatedwithcoronarya