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1、B■內(nèi)酰胺酶抑制劑治療小兒難治性肺炎臨床療效觀察呂伍梅(湖南省邵陽(yáng)市第二人民醫(yī)院湖南邵陽(yáng)422000)【摘要】目的：探討β■內(nèi)酰胺酶抑制劑治療小兒難治性肺炎臨床特點(diǎn)及療效。方法：分析了2013年6月?2014年4月我院收治的88例小兒難治性肺炎患兒的臨床資料，隨機(jī)將患兒分成觀察組44例和對(duì)照組44例。觀察組選用阿莫西林與克拉維酸合成劑治療，對(duì)照組給予頭抱哌酮舒巴坦鈉治療，比較兩組患兒治療療效及臨床癥狀、體征的消失。結(jié)果：觀察組44例中，顯效30例，有效口例，無(wú)效3例，治療總有效率為93.18%,對(duì)照組44例中，顯效
2、30例，有效10例，無(wú)效13例，治療總有效率為70.45%,觀察組治療總有效率明顯高于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)o觀察組患兒平均退熱時(shí)間及肺部癥狀平均消失時(shí)間均短于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)o結(jié)論：β■內(nèi)酰胺酶抑制劑治療小兒難治性肺炎臨床療效較好，值得推廣使用?！娟P(guān)鍵詞】β?內(nèi)酰胺酶抑制劑；小兒難治性肺炎；治療療效【中圖分類號(hào)】R720.5【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】2095-1752(2015)23-0018-02Betalactamaseinhibitors
3、inthetreatmentofchildrenwithrefractorypneumoniaclinicalcurativeeffectobservationLvWumei.TheSecondPeople'sHospitalofShaoyangCity,HunanProvinee,Shaoyang422000,China[Abstract]ObjectiveToinvestigatethebetalactamaseinhibitorsinthetreatmentofchildrenwithrefractoryclinica
4、lfeaturesandtreatmentofpneumonia.MethodsToanalyzetheclinicaldatafrom2013Juneto2014April88casesofchildrenadmittedtoourhospitalforpatientswithrefractorypneumonia,randompatientsweredividedintoobservationgroup44casesandcontrolgroupof44cases.Theobservationgroupuseofamox
5、icillinandclavulanicacidsynthesistreatment,controlgroupwasgiventhetreatmentefficacyofcefoperazonesodiumandsulbactamsodiumintreatment,comparedtwogroupsofclinicalsymptomsandsignsdisappeared.ResultsIn44casesofobservationgroup,30casesweremarkedlyimproved,effectivein11c
6、ases,3hadnoeffect,thetreatmentthetotaleffectiveratewas93.18%,controlgroupof44cases,30casesweremarkedlyeffective,effective10cases,13casesofinvalid,treatmentthetotaleffectiveratewas70.45%,totaleffectivetreatmentobservationgroupwasobviouslyhigherthanthatofcontrolgroup
7、,twogroupscomparediffereneewasstatisticallysignificant(P<0.05).Observationgroupwithaveragedefervesceneetimeandaveragepulmonarysymptomsdisappeartimeareshorterthanthecontrolgroup,comparingthetwogroupswasstatisticallysignificantdifferenee(P<0.05).ConclusionBetal
8、actamaseinhibitortreatmentchildrenrefractorypneumoniaclinicalcurativeeffectisgood,isworthpromoting.[Keywords]Betalactamaseinhibitor;Childrenrefra
