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2、芅薂螄膈蕆蒞螀膇膇蝕蚆膆艿蒃羅膅莁蚈袁膅蒃蒁螇芄膃蚇蚃袀芅蒀蕿衿莈蚅袇袈肇蒈袃袈芀螃蝿袇莂薆蚅袆蒄荿羄裊膄薄袀襖芆莇螆羃荿薃螞羃肈蒞薈羂芁薁羆羈莃蒄袂羀蒅蠆螈罿膅蒂蚄羈芇蚈薀羇荿蒀衿肇聿蚆螅肆膁葿蟻肅莄蚄蚇肄蒆薇羆肅膆莀袂肂羋薅螈肁莀莈蚄肁肀薄薀膀膂莆袈腿芅薂螄膈蕆蒞螀膇膇蝕蚆膆艿蒃羅膅莁蚈袁奧施康定治療中重度慢性癌痛的療效觀察龐東生宋志剛海軍安慶醫(yī)院腫瘤內科(246003)摘要目的:觀察奧施康定治療中重度癌痛的療效。方法:采用開放試驗方法,對40例中重度癌痛患者進行治療。奧施康定初始劑量l0mgl
3、2h-1,并根據(jù)疼痛緩解程度調整劑量。結果:40例中重度癌痛患者使用的奧施康定最小劑量l0mgl2h-1,最大劑量60mgl2h-1;治療效果:完全緩解24例(60.0%),部分緩解15例(37.5%),輕度緩解2例(5.O%)。其中中度疼痛患者的顯效率為100.0%(7/7),重度疼痛患者的顯效率為96.9%(32/33),全部患者總的顯效率為97.5%(39/40)。不良反應有:便秘15例,惡心嘔吐4例,腹脹1例,尿潴留1例,嗜睡3例,頭暈2例。結論:奧施康定治療慢性癌性中重度疼痛療效確切,有效
4、率高,不良反應輕,服用安全。關鍵詞奧施康定;癌痛;療效觀察CurativeEffectofOxycontinonModerateandSevereChronicCancerPainPANGDongsheng,SONGZhigang.DePartmentofInternalMedicineOncology,HaijunAnQingHospital.246003,ChinaABSTRACTObjective:ToobservetheanalgesiceffectofOxycontinonmoderate
5、andseverecancerpain.Methods:Openingexperiment;40patientswithmoderateandseverecancerpainwereselected.Oxycontinwasadministeredataninitialdoseof10mgevery12handtitratedupwardsaccordingtotheextentofpainrelief.Results:Thelowestandhighestdosesadministeredwere
6、l0mgl2h-1and60mgl2h-1,respectively.Amongthe40patientssufferingmoderateandsevencancerpain,24(60.0%)achievedcompleteremission,15(37.5%)achievedpartialremission,and2(5.0%)achievedminorremission.PainreliefprovidedbyOxycontinwas100%(7/7)inpatientswithmodera
7、techroniccancerpain,96.9%(32/33)inpatientswithseverechroniccancerapaintsand97.5%(39/40)forallpatientscombined.Theadversereactionswereconstipation(15cases),nauseaandvomiting(4cases),abdominaldistention(1cases),anuria(1cases),lethargy(3cases)anddizziness
8、(1case).Conclusion:Oxycontinaresafeandeffestiveformoderateandseverechroniccancerpain.Theyworkquicklywithfewsideeffects.KEYWORDSOxycontin;cancerpain;curativeeffect疼痛被定義為一種令人不快的感覺和情緒上的感受,伴隨著現(xiàn)存的或潛在的組織損傷。疼痛經(jīng)常是主觀的,不僅是一種簡單的生理應答,同時還是一種主觀的心理體驗[