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1、H1N1新型流感 疫情監(jiān)視及防治衛(wèi)生署疾病管制局防疫醫(yī)師魏嵩璽9/29/20211大綱疫情現(xiàn)況H1N1新型流感介紹我國(guó)因應(yīng)作為H1N1新型流感個(gè)案通報(bào)與採(cǎi)檢H1N1新型流感抗病毒藥劑使用H1N1新型流感病人之感控措施建議9/29/20212NovelInfluenzaH1N1intheWorld5/139/29/20213疫情等級(jí)9/29/20214臺(tái)灣疫情現(xiàn)況資料截止日期：2009/05/1312：00疾病/事件本日新增累計(jì)檢驗(yàn)結(jié)果備註陽(yáng)性陰性其他陽(yáng)性檢驗(yàn)中H1N1151500142238其他陽(yáng)性：21A/H3、1A/H1、1BH5N1070610其他陽(yáng)性：1A/H3ILIclust
2、er（事件數(shù)）0000009/29/20215H1N1:a.classicalH1N1(NorthernAmerican)b.avian-likeH1N1(European)c.triple-reassortantH1N1H3N2:a.human-likeb.reassortantsderivedfromhuman(HA),swine(N2)andavianvirusesH1N2:reassortantderivedfromthetriplereassortantH3N2virusesandclassicalH1N1swinevirusesH3N1:reassortantderived
3、fromthetriplereassortantH3N2virusesandclassicalH1N1swinevirusesMajor4subtypesofswineinfluenzaviruses9/29/20216PB2PB1PAHA-H1NPNA-N1MPNSClassicalH1N1PB2PB1PAHA-H1NPNA-N1MPNSreassortantH1N1avianPB2PB1PAHA-H3NPNA-N2MPNSHuman-likeSwineH3N2double-reassortantH3N2after1998PB2PB1PAHA-H3NPNA-N2MPNSPB2PB1P
4、AHA-H3NPNA-N2MPNSavianPB2PB1PAHA-H1NPNA-N2MPNStriple-reassortantH3N2H1N2PB2PB1PAHA-H3NPNA-N1MPNSH3N1PB2PB1PAHA-H1NPMPNSEuropeanswineH1N1NA-N1PB2PB1PAMPNSHA-H1NPNA-N1triple-reassortantH1N1PB2PB1PANSHA-H1NPMPNA-N19/29/20217HAA/California/04/2009HumanH1N1NorthernAmericanSwineH1N1AvianEuropeanSwineH
5、1N1(~75%)9/29/20218感染H1N1新型流感之癥狀H1N1新型流感癥狀與季節(jié)性流感類(lèi)似發(fā)燒、咳嗽、喉嚨痛、全身酸痛、頭痛、寒顫與疲勞有些病例出現(xiàn)腹瀉、嘔吐癥狀9/29/20219感染H1N1新型流感之癥狀一般流感潛伏期約五天，在H1N1新流感我們觀察到潛伏期最長(zhǎng)到6-8天鑑別診斷：在H1N1的病患中，約有40-50%的病患出現(xiàn)腹瀉現(xiàn)象，比一般流感腹瀉比例要來(lái)得高目前看到的大多數(shù)病患都是輕癥，而且不需住院在家休養(yǎng)即可目前在許多國(guó)家看到的感染個(gè)案，都是和旅遊相關(guān)的個(gè)案(travelrelated)南半球即將進(jìn)入冬天，要非常注意!!世界衛(wèi)生組織記者會(huì)5/4NEJM2009;36
6、11-109/29/202110H1N1新型流感傳染途徑人與人間的傳染傳染途徑與季節(jié)性流感類(lèi)似主要是透過(guò)飛沫傳染與接觸傳染一般成人在癥狀出現(xiàn)前1天到發(fā)病後7天均有傳染性，但對(duì)於病程較長(zhǎng)之病患，亦不能排除其發(fā)病期間繼續(xù)散播病毒另兒童病例的可傳染期通常較成人病例為長(zhǎng)。9/29/202111流感病毒之分類(lèi)上呼吸道流感病毒H1N1,H3N2,B高傳染率,低死亡率以社區(qū)傳染為主Immuneprotection：治療以抗病毒藥為主下呼吸道流感病毒H5N1低傳染率,高死亡率以院內(nèi)傳染為主Immunedestruction：治療以類(lèi)固醇為主From王任賢指揮官9/29/202112WhyH5N1Inf
7、luenzaAVirusInfectionResultsinHighMortality？WhatarethemolecularbarriersAvianinfluenzavirusesreplicatepoorlyinhuman,H5N1virusspecificforalpha-2,3-linkedsialosaccharides(SAα2,3Gal)Humantracheahaspredominantlyalpha-2,6-linkedsi
