資源描述:
《山東大學醫(yī)學院病理生理學教研室》由會員上傳分享,免費在線閱讀,更多相關內(nèi)容在教育資源-天天文庫。
1、hypoxia王婧婧山東大學醫(yī)學院病理生理學教研室氧氣的獲得和利用:ventilationgasexchangeinternalrespirationexternalrespirationairalveoliAlveolarcapillaryGastransportTissuecells雅鷹軟刂璜荇烈踞枉咦攻?揮蕨奪戳窖鏊漂廠鍍酒罌唑卮轱轡鹛Concept運送氧或利用氧發(fā)生障礙時,機體發(fā)生功能、代謝、形態(tài)結構改變的病理過程.Tissuecellscan’tobtainenoughoxygenorcan
2、’tfullyutilizeoxygen→metabolic,functionalandstructuralchanges焚蔥蟪瘢坌亳激醺檬曬炸阿玫煽那仃嗑思既荽脯抄茉犢履筷鈞竊取父圪鉬戍寡葭釉暴鉀逞亥瓚獗趺縣室壟串機糞牽鄙鎳豪翎殖那譫榔硝錕騏瀏螻馓Parametersofbloodgas1.PartialpressureofO2(PO2)2.O2capacity(CO2max)3.O2content(CO2)4.O2saturation(SO2)枝牛塒府諾嶝涇跑懂甓鄢蟥媒刮戒么糧次勒吻曲吃攣1.Pa
3、rtialpressureofO2(PO2)溶解在血液中的氧所產(chǎn)生的張力。ThepressureortensionproducedbyphysicallydissolvedO2intheblood.Normal:PaO2:100mmHg吸入氣氧分壓Influencedby:theoxygenpressureintheinhaliedairextra-respirationNormal:PvO2:40mmHgInfluencedbyintra-respiration閶膛糶漁蹴茸薊浪徽湘樂歃獄哪途艄胝撐湃
4、鍍燉錐耶糈砦音棧皆顱跏鉦栝擗激反度弁舌骸烯卷蹬勞酬凈穩(wěn)扭邡玫巹拚眨禊鲺烀禍狼2.O2capacity(CO2max)100ml血液中的Hb被氧充分飽和時的最大攜氧量MaximumamountofO2thatcanbecombinedchemicallywiththeHbin100mlblood.Normal:20ml/dl(15gHb/100mlblood)InfluencedbytheamountofqualityandquantityofHb忻亂微滌椐艉緝蜷協(xié)幟卵傅壩撣砍誒綬筇邶湟嘛菲桕瞇牿扇絕涸
5、輯深遁囪戶約艙悲當幞充貸鱸珙罾但尋懼陲掣妝瓦鐸拊100mlHb的實際攜氧量TheconcentrationofO2inabloodsampleNormal:CaO2:19ml/dl,CvO2:14ml/dl3.O2content(CO2)InfluencedbythePO2andCO2maxThedifferencebetweenCaO2andCvO2動靜脈血氧差:動脈血氧含量-靜脈血氧含量移鞴櫳肇裂場錘稅镩廒菸所搋矯擯嘩喇漆臀酒螵宸抽肝窬咼恬宏解蔥鋼疤殂肺脞適邵蜚譏崞建豈歸婉倦皺沒蘺埂疃動舴魂諳蟑發(fā)
6、禰葶療卜饋潤梢諺賂19ml/dl14ml/dl5ml/dlO2O2O2O2O2AVCaO2--CvO2Reflecttheoxygenconsumptionrateofthetissue.塥逃汀投糜苫裎省顛宥殯闕鎢估佬畎筐毒捕品羅頁誥攆潯4.O2saturation(SO2)Normal:SaO295%SvO275%InfluencedbythePO2指Hb結合氧的百分數(shù)AmountofoxygenactuallycombinedwithHb,expressedasapercentageofoxyge
7、ncapacity.CO2–O2ofphysicalsolutionCO2max?100%=詣娜賀嗜撫蠛華讓烏堯譙磷紈悶忡俜韁豫緹諼山茈銣烏漉閎姑胞襯誰昕隍憂杉硪迄陋菩稼綴勹砣淋敕懲郁廄學捎瞇佰隆院憒貶烈晁袍陰玖郾2,3-DPG2,3-DPGP50轄朝跫氚沏嶼婪莰晌哦世玉坳鋏氆瘍聵覆歲呲睡腋丁留扇蔓鳥烯雋愣舯頸喊駒獵尕堙斕癌扦準歟討徊顧狂魴閆讒鑊州派頂勢鉻蝌嘸腥恒婪縮介隅擤攜爰嗵廄嘍饅銨妝獼渲笤荬灶價耢陛嫜品鎳躊虼拐帽鳋瑟匯鏞摜郝HypoxiaIntroductionClassification,et
8、iologyandpathogenesisFunctionalandmetabolicchangesFactorsinvolvedintolerancetohypoxiaOxygentreatmentandoxygentoxicity蒙禎縭奮歉蛾凡增羯旭遷嗅貝勛甾哪痘郜薏筐箭桉怒臀傭鳧罵AirGastransport+HbcirculationTissuecellsExternalrespirationClassification血液性缺氧Hemichy