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1、5-FU與得寶松聯(lián)合治療瘢痕疙瘩療效觀察狄美華上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院整復(fù)外科門診手術(shù)室，200011摘要［目的］:觀察低濃度(0.25%)5-氟尿卩密噪與得寶松混合注射治療瘢痕疙瘩的效果。［方法h將木組的92例患者分成治療組和對(duì)照組兩組，均行瘢痕疙瘩的全層注射，對(duì)治療組的46例患者行5-Fu與得寶松的混合液，對(duì)對(duì)照組的46例患者行單純得寶松注射，每隔3-4周注射，一個(gè)療程為2-3次，隨訪6-12個(gè)月。［結(jié)果］:治療組痊愈率52.2%,有效率93.5%,對(duì)照組痊愈率26.1%,有效率54.3%,1X0.01
2、,兩組差異存在顯著性。［結(jié)論］:低濃度5-Fu與得寶松聯(lián)合治療瘢痕疙瘩增生與復(fù)發(fā)、止癢、止痛有較好的效果。［關(guān)鍵詞］:瘢痕疙瘩5-氟尿喘喘得寶松ABSTRACT［Objective］Toobservetheinjectiontreatmenteffectsofkeloidswithmixtureoflowconcentration(0.25%)5~Fuanddiprospan.［Methods］92patientswasdividedintotreatmentgroup(TG)thatreceivedmixturei
3、njection,andcontrolgroup(CG)thatreceivedonlydiprospan.Bothgroupswereadministcredwithfull-thickncssinjectionofkeloids,2to3times,onceevery3to4weeks,andfollowedupfor6to12months.［Results］Recoveryratewas52.2%inTGand26.1%inCG,effectiveratewas93.5%inTGand54.3%inCG.The
4、reissignificanlstatisticaldiffereneebetweenthetwogroups.5-FU與得寶松聯(lián)合治療瘢痕疙瘩療效觀察狄美華上海交通大學(xué)醫(yī)學(xué)院附屬第九人民醫(yī)院整復(fù)外科門診手術(shù)室，200011摘要［目的］:觀察低濃度(0.25%)5-氟尿卩密噪與得寶松混合注射治療瘢痕疙瘩的效果。［方法h將木組的92例患者分成治療組和對(duì)照組兩組，均行瘢痕疙瘩的全層注射，對(duì)治療組的46例患者行5-Fu與得寶松的混合液，對(duì)對(duì)照組的46例患者行單純得寶松注射，每隔3-4周注射，一個(gè)療程為2-3次，隨訪6-12
5、個(gè)月。［結(jié)果］:治療組痊愈率52.2%,有效率93.5%,對(duì)照組痊愈率26.1%,有效率54.3%,1X0.01,兩組差異存在顯著性。［結(jié)論］:低濃度5-Fu與得寶松聯(lián)合治療瘢痕疙瘩增生與復(fù)發(fā)、止癢、止痛有較好的效果。［關(guān)鍵詞］:瘢痕疙瘩5-氟尿喘喘得寶松ABSTRACT［Objective］Toobservetheinjectiontreatmenteffectsofkeloidswithmixtureoflowconcentration(0.25%)5~Fuanddiprospan.［Methods］92pati
6、entswasdividedintotreatmentgroup(TG)thatreceivedmixtureinjection,andcontrolgroup(CG)thatreceivedonlydiprospan.Bothgroupswereadministcredwithfull-thickncssinjectionofkeloids,2to3times,onceevery3to4weeks,andfollowedupfor6to12months.［Results］Recoveryratewas52.2%in
7、TGand26.1%inCG,effectiveratewas93.5%inTGand54.3%inCG.Thereissignificanlstatisticaldiffereneebetweenthetwogroups.[Conelusion]Combinationoflowconcentrationof5-Fuanddiprospancangetsatisfactoryresultsforkeloidswithproliferation,recurrence,itchyandpain.[keywords]Kel
8、oids,5-Fu,diprospan刖s瘢痕疙瘩是創(chuàng)傷愈合領(lǐng)域的一個(gè)難題，其形成機(jī)理尚不清楚，冃前尚無一種理想的治療方法，而且治療后易于復(fù)發(fā)"3手術(shù)后發(fā)牛瘢痕疙瘩的病例也較多,瘢痕生t速度快，增牛明顯，多呈瘤樣。盡管激素注射治療瘢痕疙瘩有一定的效果，但由于激素的副作用及對(duì)人體生長發(fā)育的影響，其應(yīng)用受到一定的限制。5-氟廉卩密陀(5-Fu)為抗
