口服普萘洛爾治療40例面頸部嬰幼兒血管瘤的臨床觀察

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1、口服普蔡洛爾治療40例面頸部嬰幼兒血管瘤的臨床觀察口服普蔡洛爾治療40例面頸部嬰幼兒血管瘤的臨床觀察［摘要］目的：評價普蔡洛爾口服治療嬰幼兒血管瘤的臨床療效及不良反應(yīng)。方法:對40例而頸部血管瘤患兒進行口服普蔡洛爾治療，并以32例強的松治療的血管瘤患兒作對照。治療組予口服普荼洛爾加g/(kg■d),分2次服用。住院治療3?4天，為安全起見,第1天服全量的1/4,第2天服全量的1/2,第3天服全量。若無異常就可出院，且出院后繼續(xù)按原劑量服藥。每2?3周復(fù)診1次，并觀察瘤體的大小、質(zhì)地、顏色，隨訪和同時針對藥物的不良反應(yīng)進

2、行處置；對照組采用口服強的松3mg/(kg?d),隔日1次，晨起時頓服，兩組患者各自用藥后，根據(jù)病變的生長、萎縮并穩(wěn)定或服藥時間滿6個月為停藥指征。按4級評分法(優(yōu)、好、中、差)對近期療效進行評價。結(jié)果：療效統(tǒng)計，治療組：優(yōu)12例(30.00%),好21例(52.50%),中5例(12.50%),差2例(5.00%),有效率82.50%；對照組：優(yōu)5例(15.62%),好9例(28.12%),中12例(37.50%),差6例(18.75%),有效率43.75%。治療組與對照組的有效率比較差異有統(tǒng)計學(xué)意義(P<0.05)

3、o治療組不良反應(yīng)發(fā)生率7.5%,對照組為56.25%,兩組比較差異有統(tǒng)計學(xué)意義(P<0.05)o結(jié)論：普蔡洛爾口服治療嬰幼兒血管瘤的方法有效，不良反應(yīng)少，值得臨床推廣應(yīng)用。［關(guān)鍵詞］血管瘤；嬰幼兒；普蔡洛爾；強的松［中圖分類號］R739.5［文獻標(biāo)識碼］A［文章編號11008-6455(2014)14-1177-04Clinicalobservationofpropranololtakenorallyto40casesofinfantilehaemangiomasZHANGLi,CHENYong,YIGuang-jia

4、o(DepartmentofOralandMaxillofacialSurgery,TheSecondPeople，sHospitalofYunnanProvince,Kunming650021,China)Abstract：ObjectiveToinvestigatetheclinicedefficacyandadverseeffectsofpropranololtakenorallyinfantilehaemangiomas?MethodsBetweenFebruary2010andFebruary2013,40i

5、nfantswithheamangiomaswereusedasstudygroupbyusingpropranolol.Atadoseof2.Omg/(kg?d),bydividinginto2timeswithcontinuousmedication.Thepatientswerehospitalizedfor3?4days.Forsecurity,thefirstdayused1/4ofthefulldoes,theseconddayused1/2offulldoes,andthethirddayusedthef

6、ulldoes?Iftherewasnoabnormalphenomena,continuedmedicationwithformerdoesaftertheyleavedthehospital.Takeasubsequentvisitafter2~3weeks,observingandrecordingthechangesoftumorsize,textureandcolor,theadverseeffectsaftermedicationwereobservedandmanagedaccordinglyatareg

7、ularintervaL32infantswithheamangiomaswereusedascontrolgroupmaterialsbyusingprednisone.Atadoseof3mg/(kg?d),thenextdaybefore8am.Takenatadraught?Afterthetreatmentbetweenthesetwogroups,thewithdrawalindicationswerethegrowthoftumor,theshrinkandstabilizeoftumorortaking

8、timeto6months?Theshort-termresultswereevaluatedbyusinga4-pointscalesystem(excellent,good,moderate,poor)?ResultsIngroupofpropranplolorally.Theoverallresponseofexcellen