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1、Reviewarticle1審查第1條Asystematicreviewofraltitrexed-basedfirst-linechemotherapyinadvancedcolorectalcancerSandroBarnia,AntonioGhidinib,AndreaCoinua,KarenBorgonovoaandFaustoPetrellia雷替曲塞為基礎(chǔ)的一線的系統(tǒng)評價化療在晚期大腸癌桑德羅Bamia,安東尼奧Ghidinib,安德烈Coinua,卡倫Borgonovoa和福斯托PetrelliaRaltitrcxcdisathymidylatesynthaseinhibit
2、orbelongingtotheantinietaboliteclassofcytotoxicdrugs?Itisalsocttcctivcincolorectalcancer(CRC)bothasasingleagentandincombinationwithotherdrugs,inparticularinthosepatientswithcardiologicriskfactorsorpreviouscardiotoxicity.TheetTicacyoffirst-lineraltitrexed-basedchemotherapycontainingoxaliplatin(TOMO
3、X)andirinotecan(TOMIRI)wasinvestigatedinthissystematicreview.StudiesthatenrolledadvancedCRCpatientsforfirst-linetherapywithTOMOX/TOMIRIcombinationswereidentifiedusingelectronicdatabases(Pubmed,SCOPUS,WebofScience,EMBASE,andtheCochraneLibrary).AsystematicanalysiswascarriedoutusingComprehensiveMetaA
4、nalysis(version2.2.064)softwaretocalculatethepooledresponserateand95%confidencelimits?Themedianpooledoverallsurvivalandprogrcssion-frccsurxivalwerealsocalculated.ResultsforTOMOXandTOMIRIstudieswerecomparedusingthetwo-sidedStudenCst-test.WetestedforsignificantheterogeneityusingCochran'sx^-testandbi
5、ndex?Twelvestudiespublishedbetween2001and2012wereeligibletorthisanalysisandatotalof735patientswereenrolledinthesestudies?Theoverallresponseratewas40%(95%confidenceintcnal34-46%):43.9%forTOMOXand34.1%forTOMIRIarms.Theweightedmedianoverallsurxivaland雷替曲塞是屬于胸昔酸合成酶抑制劑抗代謝物類的細胞毒性藥物。它也有效的結(jié)直腸癌(CRC：)既作為一個單
6、一的代理并與其他藥物,尤其是在那些組合患者的心源性危險因素或以前心臟毒性。一線的雷替曲塞為基礎(chǔ)的療效含奧沙利鉗化(TOMOX)和伊立替康(TOMIRI)在本系統(tǒng)進行了研究審查。該研究入選晚期CRC患者一線治療TOMOX/TOMTRT組合為使用電子數(shù)據(jù)庫(考研，SCOPUS確定，科學(xué)，醫(yī)學(xué)文摘和Cochrane圖書館的網(wǎng)絡(luò))。progrcssion-frccsunivaltimeswere14.6and6.7months,respectively.NeutropeniaandlivertoxicityweremorefrequentwithTOMOX,whereasneutropeniaan
7、ddiarrheaweremorefrequentwithTOMIRI.However,comparedwithhistoricalFOLFOXandFOLFIRItrials,raltitrexed-baseddoubletsareass(x:ialedwithlessneutropeniaandgastrointestinaltoxicityanduncommoncardiotoxicity.TOMOXandTOMI
