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《納洛酮干預(yù)治療重度新生兒缺氧缺血性腦病對(duì)預(yù)后影響的臨床.doc》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。
1、納洛酮干預(yù)治療重度新生兒缺氧缺血性腦病對(duì)預(yù)后影響的臨床研究Sodiumnaloxoneinterventiontreatmentofsevereneonatalhypoxic-ischemicencephalopathyinflueneeontheprognosisofclinicalresearch作者：廣東省江門(mén)市第二人民醫(yī)院兒科：梁光明副主任醫(yī)師鄭瓊副主任醫(yī)師甘曉紅副主任醫(yī)師Author:JiangmenCity,GuangdongProvinee,theSecondPeople'sHospitalofPediatrics:LiangGuangming,d
2、eputydirectorofPhysiciansZhengQiong,deputychiefphysicianGanXiaohong,deputydirectorofPhysicians摘要：目的探討新生兒缺氧缺血性腦病給予納洛酮干預(yù)治療的臨床評(píng)分及對(duì)新生兒缺氧缺血性腦病NBNA評(píng)分及預(yù)后的影響。方法對(duì)￡12006年1月?2011年12月收治的42例重度新生兒HIE患兒隨機(jī)分為兩組治療組23例及對(duì)照組17例，對(duì)照組給予常規(guī)治療，治療組在常規(guī)治療的基礎(chǔ)上加用納洛酮，7?14d為一個(gè)療程，比較兩組的臨床評(píng)分及神經(jīng)行為NBNA評(píng)分。結(jié)果治療組與對(duì)照組臨床評(píng)分比較差異
3、有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組不同時(shí)間NBNA評(píng)分比較治療1?3d后兩組NBNA評(píng)分比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05):治療7?14d后兩組NBNA評(píng)分比較差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論新生兒缺氧缺血性腦病給予納洛酮干預(yù)治療可以明顯降低新生兒缺氧缺血性腦病病兒的臨床評(píng)分和提高NBNA評(píng)分，改善新生兒缺氧缺血性腦病的臨床評(píng)分及體征，明顯提高了新生兒缺氧缺血性腦病預(yù)后的存活率，降低了死亡率，值得推廣應(yīng)用。關(guān)健詞：納洛爾干預(yù)新生兒缺氧缺血性腦病Summary:PurposeNeonateswithhypoxicischemicencephalopathy
4、clinicalscoregiventothenaloxoneinterventiononneonatalhypoxic-ischemicencephalopathytheNBNAscoreandprognosisof.Method23casesfromJanuary2006toDecember2011were42casesofsevereneonatalHIEwererandomlydividedintotwotreatmentgroupsandcontrolgroup(n=17),thecontrolgroupreceivedconventionalther
5、apy,thetreatmentgroupintheconventionaltreatmentbasedonplusnaloxone,7-14dasacourseofclinicalscoresandneurobehavioralNBNAscoreswerecomparedbetweenthetwogroups?ResultClinicalscoreofthetreatmentgroupandcontrolgroupthediffereneewasstatisticallysignificant(P<0.05).NBNAscoresoftwodifferentt
6、imetreatment1~3dNBNAscoredifferencebetweenthelattertwogroupswasstatisticallysignificant(P>005);treatmentof7~14daftertwosetsoftheNBNAscorediffereneewasstatisticallysignificant(P<0.05).ConclusionNeonatalhypoxic-ischemicencephalopathynaloxoneinterventioncansignificantlyreducetheclinical
7、scoreofneonatalhypoxic-ischemicencephalopathydiseaseofchildrenandimproveNBNAscoreimprovedneonatalhypoxic-ischemicencephalopathy,theclinicalsymptomsandsigns5significantlyimprovethesurvivalofneonatalhypoxic-ischemicencephalopathy,theprognosis,reducingmortality,shouldbewidelyapplied?Key
8、words:Sodium
