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1、·1100·王鶴令，等PEDF與VEGF在肝外膽管癌中的表達及意義PEDF與VEGF在肝外膽管癌中的表達及意義王鶴令，梁博，劉鵬，周品一，張宇ExpressionandsignificanceofPEDFandVEGFinextra—-hepaticcholangiocarcinomaWangHeling，LiangBo，LiuPeng，ZhouPinyi，ZhangYu。DepartmentofGeneralSu~ery，TheShengjingAffiliatedHospital，ChinaMedwal
2、University，LiaoningShenyang110022，China；DepartmentofGeneralSurgery，CentralHospitalofAnshanCity，LiaoningAnshan114000，China．【Abstract】0bjective：ThePEDFandVEGFexpressioninextrahepaticbileductcarcinomatissueandnormaltis—suewereassessedbyimmunohistochemistrytos
3、tudythecorrelationbetweentheexpressionofPEDFandVEGF．AndwealSOconcernwiththerelationshipbetweentheirexpressionandeholangioearcinoma．Methods：Collectextrahepaticbileductcarcinomatissuefrom70cholangiocarcinomapatientsnormaltissuefrom30cho1ecystolithiasi8patien
4、tsbileductthatnoiflammationasthesamplesinthestudy．PatientswereallpostoperativeandpathologicalconfirmedinthesurgerydepartmentofShengjingHospitalofCMUfromJanuary，2006toMay，2010．ThePEDFandVEGFexpressionswereassessedbyimmunohistochemistry，andthedatawasanalyzed
5、bySPSS19．0．Results：ThepositivesignalofPEDFexpressionwasstainedyellowandmainlylocatedinthecellcytoplasmaandonthecellmembrane．Itmainlyexpressednegativeorweakpositiveincarcinomatissueandpositiveorweakpositiveinnormaltissue．ThepositivesignalofVEGFexpressionwas
6、stainedyelloworbrownandmainlylocatedinthecellcytoplasmaandonthecellmembrane．Itmainlyexpressedpositiveincarcinoma，butnegativeorweakpositiveinnormaltissue．Therewasnega-tivecorrelationbetweenPEDFandVEGFexpressions(r=一0．392，P<0．05)．PEDFandVEGFexpressionshowedt
7、hecorrelationwithlymphnodemetastasisandneoplasmstaging，butwithnocorelationwithtumorsizeorhistologicalgrades．Conclusion：LowexpressionofPEDFhasthecorrelationwithoccurence，development，invasionandmetasta-sisofcholangiocarcinoma．HighexpressionofVEGFhasthecorela
8、tionwithoccurrence，development，invasionandme—tastasisofcholangioearcinoma．PEDFandVEGFhaveaconversefunctioninthedevelopmentofcholangiocarcinoma．【Keywords】ch0langi0carcinoma；PEDF；VEGFModernOneology2014，22(05)：1
