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1、JournalofChinesePharmaceuticalScienceshttp://www.jcps:ae;enChemicalconstituentsfromtheleavesofPremnamicrophyllaTurczZhengxiHu,YongboXue,GuangminYao,ZengweiLuo,YanyanWang,YonghuiZhangJ.HubeiKeyLaboratoryofNaturalMedicinalChemistryandResourceEvaluation,
2、SchoolofPharmacy,TongfiMedicalCollegeHuazhongUniversityofScienceandTechnology,Wuhan430030,China2.FirstCollegeofClinicalMedicalScienceofChina,ThreeGorgesUniversity&IqchangCentralPeople'sHospital,Yichang443003,ChinaCLCnumber:R284Documentcode:AArticleID:
3、1003-1057(2013)5M31-041.IntrOductiOnThegenusPremna(Verbenaceae),widelydistributedinHH×火HOHtropicalandsubtropicalareas,suchasAsia,Africa,.I八Australia.a(chǎn)ndthePacificislandsiSallimportantmedicinalHplant[IJThisgenusconsistsofmorethan200speciesin.3theworld,
4、ofwhichabout45speciesaredistilbutedinChina.Sofarseveralditerpcnes,sequitcrpcnes,iridoids,andflavonoidshavebeenisolatedandidentifiedfromthisgenus,andtheywerefoundtoshowawidespectrumofHpharmacologicaleffects,suchasanticancer,antibacterial,OHantifunga1.a(chǎn)
5、ndanti—leishmaniaactivitiesThespecies456P.microphyllaTurcziSlocallyknownas“DOUfuchai”inChina.widelyusedtotreatdysenteryandappendicitisjyo。。Atpresent,therelatedstudiesonthisplantfocusonthe~nutritionandproteinsafetyofits1eaves,whilethere叩pear?Hd.oHH,toh
6、avebeenrarelypreviousstudiesonthebioactivecon—79stituents.Asanefforttodiscoverthenewanticanceragentsfromnatureresource,aphytochemicalinvestigationonthechloroform.solubleextractoftheplant1edtotheisolationof13knowncompounds(Fig.1),andcompounds2-13areiso
7、latedfromthisgenusforthefirsttime.H2.Experimental2.1.GeneralproceduresNMRspectrawererecordedonaBrukerAM——400Received:2013—0228;Revised:20l3-03—25;Accepted:2013-04-02.HHFoundationitems:NationalNaturalScienceFoundationOfChinarGrantNo.31270390)andProgram
8、forNewCenturyExcellentHTalentsinUniversity(GrantNo.NCET-08—0224).H2324Correspondingauthor.Te1.:+86-717-6487741:+86—27-836923ll;E—mail:wangyyl001@163.corn;zhangyh@mails.tjmu.edu.cnhttp://dx.doi.org/1O.5246@ps.2013.05.063Figure1.Chemicalstructur