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1、腫瘤基礎(chǔ)與臨床2011年10月第24卷第5期?397?局部晚期宮頸癌術(shù)前新輔助化療的應(yīng)用價(jià)值趙曉東,吳為群,茅紅艷,梁向華(啟東市人民醫(yī)院,江蘇啟東226200)摘要:目的評(píng)價(jià)新輔助化療對(duì)于局部晚期宮頸癌的術(shù)前療效和手術(shù)效果。方法新輔助化療組32例局部晚期宮頸癌術(shù)前進(jìn)行2個(gè)周期的TP方案化療,化療結(jié)束后2~3周行廣泛全子宮切除加盆腔淋巴結(jié)清掃術(shù),并以同期相同條件的直接手術(shù)的32例局部晚期宮頸癌作為對(duì)照,觀察化療前后腫瘤大小、SCC值的變化和化療毒副反應(yīng),并對(duì)兩組手術(shù)情況和術(shù)后病理進(jìn)行比較分析。結(jié)果新輔助化療組患者化療后腫瘤明顯縮小(P<0.05),其中
2、3例達(dá)到CR,20例達(dá)到PR,總有效率為71.88%;SCC值也明顯下降(P<0.05);患者對(duì)化療毒副反應(yīng)均能耐受。與對(duì)照組相比,手術(shù)時(shí)間明顯縮短,出血量明顯減少,淋巴結(jié)陽性率、脈管受侵率及宮旁累及率顯著降低(P<0.05)。結(jié)論局部晚期宮頸癌術(shù)前新輔助化療安全有效,有利于腫瘤切除,可提高患者生活質(zhì)量。關(guān)鍵詞:局部晚期宮頸癌;新輔助化療;手術(shù)中圖分類號(hào):R737.33;R730.53文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1673-5412(2011)05-0397-03TheApplicationValueofPreoperativeNeoadjuvantCh
3、emotherapyintheTreatmentofPatientswithLocallyAdvancedCervicalCancerZhaoXiaodong,WuWeiqun,MaoHongyan,LiangXianghua(QidongPeoplesHospital,Qidong226200,China)Abstract:ObjectiveToinvestigatethepreoperativeandoperativeeffectsofneoadjuvantchemotherapyinthetreatmentofpatientswithlocall
4、yadvancedcervicalcancer.MethodsTwocyclesofTPregimenchemotherapyweregiventothe32patientswithlocallyadvancedcervicalcancerbeforetheoperationintheneoadjuvantchemotherapygroup,thenradicalhysterectomyandpelviclymphadenectomyweregivenfor23weekslater.Theother32patientswiththesamecondit
5、ionreceivedprimarysurgeryasthecontrolgroup.Thetumorsize,thechangeofSCCandthechemotherapytoxicitieswereobservedbeforeandafterchemotherapy,andthesituationofoperationandthepostoperativepathologywerecomparedbetweenthetwogroups.ResultsThetumorsweresmallersignificantlyafterchemotherapy
6、intheneoadjuvantchemotherapygroup(P<0.05),amongthe32patients,the3casesgotCR,the20casesgotPR,thetotalresponseratewas71.88%;SCCdecreasedsignificantly(P<0.05);allthepatientscouldtoleratethechemotherapytoxicities.Comparedwiththecontrolgroup,theoperationtimewasshortenedsignificantly,th
7、eamountofbleedingwasreducedsignificantly,therateoflymphnodemetastasis,theinvasionrateofintravascularandtheinvolvementrateofparametriumdecreasedsignificantlyintheneoadjuvantchemotherapygroup(P<0.05).ConclusionPreoperativeneoadjuvantchemotherapyinthetreatmentoflocallyadvancedcervic
8、alcancerissafeandeffective
