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1、腫瘤基礎(chǔ)與臨床2011年6月第24卷第3期·213·術(shù)前新輔助化療治療局部晚期宮頸癌臨床療效的觀察11112侯巖峰，程曉偉，承莉，俞小元，萬美珍(1．蘇州大學(xué)附屬常州市腫瘤醫(yī)院婦瘤科;2．病理科，江蘇常州213001)摘要:目的探討Ⅰb2～Ⅱb期局部晚期宮頸癌于根治術(shù)前給予新輔助化療(NACT)的療效。方法回顧性分析48例Ib2～Ⅱb期局部晚期宮頸癌NACT1～2療程后根治性手術(shù)者(NACT組)和38例直接根治性手術(shù)者(對照組)的臨床資料，評價NACT在宮頸癌治療中的作用及安全性。結(jié)果術(shù)前NACT總有效率77．1%，化療毒副反應(yīng)輕。NACT組宮旁及陰道切緣陽性率低
2、于對照組(P＜0．05)。兩組手術(shù)時間、術(shù)中出血量、術(shù)后留置尿管時間、并發(fā)癥發(fā)生率比較差異無統(tǒng)計學(xué)意義(P＞0．05)。結(jié)論Ⅰb2～Ⅱb期局部晚期宮頸癌術(shù)前NACT效果好，能使腫瘤病灶縮小，宮旁組織浸潤消退，為根治性手術(shù)創(chuàng)造條件。關(guān)鍵詞:宮頸癌;新輔助化療;宮頸癌根治術(shù)中圖分類號:R737．33;R730．53文獻(xiàn)標(biāo)識碼:A文章編號:1673－5412(2011)03－0213－03TheClinicalObservationoftheTherapeuticEffectofNeoadjuvantChemotherapyonPatientswithLocalAdva
3、ncedCervicalCarcinomaHouYanfeng，ChengXiaowei，ChengLi，YuXiaoyuan，WanMeizhen(1．DepartmentofGynecologyandOncology;2．DepartmentofPathology，ChangzhouTumorHospitalAffiliatedtoSoochowUniversity，Changzhou213001，China)Abstract:ObjectiveToexploretheclinicaltherapeuticeffectofneoadjuvantchemothe
4、rapy(NACT)onlocallyadvancedstageIb2-Ⅱbcer-vicalcarcinoma．MethodsWeretrospectivelyanalyzed48patientswithbulkystagerⅠb2-Ⅱbcervicalcarcinoma(theNACTgroup)whore-ceived1-2coursesoftreatmentwithNACTandthenunderwentradicalhysterectomyinallofthem，and38patiens(thecontrolgroup)whore-ceivedradic
5、alhysterectomy．Theeffectandsafetyofchemotherapyonthetreatmentofcervicalcarcinomawereassessed(bythelesionsize，toxicties，operativestatus，andpathology)．ResultsTheeffectiverateofNACTwas77．1%，andthetoxictieswereweak．AfterthetreatmentwithNACT，thepathologicalparametrialandvaginaedgepositiver
6、ateintheNACTgroupwassignificantlylowerthanthatinthecontrolgroup(P＜0．05)．Therewerenosignificantdifferencesinsurgerytime，bloodloss，indwellingcathetertimeandtheincidenceratesofcomplicationsbetweenthesetwogroups(P＞0．05)．ConclusionPreoperativeNACTiseffectiveforlocallyadvancedstageⅠb2-Ⅱbcer
7、vicalcarcinoma，candiminishtumorsize，decreasetumortissueinfiltration，andcreatethegoodconditionstoradicalsurgery．Keywords:cervicalcarcinoma;neoadjuvantchemotherapy;radicalhysterectomyofcervicalcancer子宮頸癌是女性最常見的惡性腫瘤之一，死亡率在我院婦科住院、通過病理及臨床確診、分期為Ⅰb2較高。臨床上治療多采用手術(shù)和放療治療，但對局部～Ⅱb期的局部晚期宮頸癌患者48例(NA
8、CT組)，
