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1、選擇性丘腦腹中間核毀損術(shù)治療震顫型帕金森病論文.freel)毀損術(shù)的手術(shù)方法及對(duì)震顫型帕金森病的療效.方法CT解剖定位,微刺激、微記錄及放大刺激進(jìn)行神經(jīng)電生理校對(duì),行小灶性毀損.手術(shù)前后行UPDRS分項(xiàng)計(jì)分、手指拍擊實(shí)驗(yàn)和行走試驗(yàn)并計(jì)算改善率.結(jié)果33例震顫型帕金森病患者術(shù)中完全控制震顫.UPDRS分項(xiàng)計(jì)分、手指拍擊實(shí)驗(yàn)和行走試驗(yàn)及改善率均顯示手術(shù)療效顯著.2毀損術(shù)對(duì)震顫型帕金森病有顯著療效.嚴(yán)格掌握手術(shù)適應(yīng)證,合理應(yīng)用微電極技術(shù),適當(dāng)?shù)臍p體積是手術(shù)成功的關(guān)鍵.Keyor;thalamus;stereotaxictechniquesAbstract:AIMTodiscussthemet
2、hodandtheouteofselectiveventralisintermediusnucleusthalamotomyformedi-callyrefractorytremorofParkinson’sdiseasepatients.METHODSAfteranatomicallocalizationingthetargetbymicrostimulation.freelicrorecordingandmarcostimulationasmalllesionade.Subpo-nentsoftheUPDRS,orsorofapatienthadbeenfoundagaintaine
3、dthreemonthslateralthoughimprove-mentthalamoto-myisabettertreatmentformedicallyrefractorytremorofParkinsons’sdiseasepatients.Indications,techniqueofmi-crorecordingandlesionvolumearethebasisofsuccessinop-eration.0引言丘腦腹中間核(ventralisintermediusnucleus,Vim)為各種震顫形成過(guò)程中的一個(gè)關(guān)鍵結(jié)構(gòu),是手術(shù)消除各種震顫最有效部位之一[1].選擇性丘腦V
4、im毀損術(shù)是指應(yīng)用微電極技術(shù)確定手術(shù)靶點(diǎn),根據(jù)Vim的軀體定位關(guān)系和患者的癥狀實(shí)現(xiàn)選擇性毀損,雖然毀損體積僅為常規(guī)手術(shù)的20%~30%,但減少了手術(shù)并發(fā)癥,提高了手術(shù)療效[2].我科自1997年10月開展此手術(shù)治療帕金森病震顫取得了一些經(jīng)驗(yàn),報(bào)告如下.1對(duì)象和方法1.1對(duì)象1997-10/1999-08采用微電極引導(dǎo)選擇性丘腦Vim毀損術(shù)帕金森病患者151例,排除同時(shí)行蒼白球毀損術(shù)103例,剩下的48例患者中,震顫型帕金森病33(男19,女14)例,年齡(58.2±10.8)歲,病史(8.4±2.3)a,服藥史(4.9±2.8)a.1.2方法應(yīng)用CR.Neuronalbasisofthe
5、parkinsonianrestingtremor:Ahypothesisanditsimplicationsfortreatment[J].Neuroscience,1990;35(2):217-226.[2]KellerTM,TchengTK,BurkhardPR,RichardH,TamasLB.Stereotacticallyguidedthalamotomyfortreatmentofparkinso-niantremorisolatedtotheloity[J].JNeurosurg,1998;89(2):314-316.[3]LozanoAM,LangAE,Galvez-J
6、imenezN,MiyasakiJ,DuffJ,Hutchinson,F(xiàn)engXJ.Micro-electrode-guidedstrerotacticsurgeryofmulti-targetsforParkinson’sdisease[J].ZhongguoShenjingJingshenJibingZazhi(ChinJNervMentDis),2000;26(1):27-30.[5]LinharesMN,TaskerRR.Microelectrode-guidedthalamotomyforParkinson’sdisease[J].Neurosurgery,2000;46(2)
7、:390-395.[6]OhyeC,F(xiàn)ukamachiA,MiyazakiM,IsobeI,NakajimaH,ShibazakiT.PhysiologicallycontrolledselectivethalamotomyforthetreatmentofabnormalmovementbyLeksell’sopensys-tem[J].ActaNeurochir(,F(xiàn)engXJ,LiLH.Therolemicroelectrod