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1、萬(wàn)方數(shù)據(jù)復(fù)旦大學(xué)醫(yī)學(xué)博士研究生畢業(yè)論文蟾毒它靈對(duì)惡性膠質(zhì)瘤的作用及機(jī)制的研究m1一,'-1‘,’‘n·1‘lnee士teCtandmeCnanlSm0士10U士Ota上1nOnms/1gnantg上101118●●一’●專(zhuān)業(yè):外科學(xué)姓名:高幸指導(dǎo)教師:毛穎教授導(dǎo)師組成員:張榮教授趙曜教授姚瑜副教授花瑋博士萬(wàn)方數(shù)據(jù)目錄縮略詞表????????????????????1中文摘要????????????????????3英文摘要????????????????????6引言???????????????
2、??????10參考文獻(xiàn)???????????????????..12第一部分蟾毒它靈在體外對(duì)人膠質(zhì)瘤細(xì)胞的生長(zhǎng)抑制作用評(píng)價(jià)????15材料和方法???????????????????15實(shí)驗(yàn)結(jié)果???????????????????..20討論?????????????????????29結(jié)論?????????????????????33參考文獻(xiàn)???????????????????..33第二部分蟾毒它靈對(duì)人膠質(zhì)瘤異體種植動(dòng)物模型的抗腫瘤藥效研究??..39材料和方法?????????????
3、??????39實(shí)驗(yàn)結(jié)果???????????????????..46討論?????????????????????53結(jié)論?????????????????????56參考文獻(xiàn)???????????????????..56第三部分蟾毒它靈對(duì)人膠質(zhì)瘤細(xì)胞生長(zhǎng)抑制作用機(jī)理的研究????..61材料和方法???????????????????61實(shí)驗(yàn)結(jié)果???????????????????..65討論?????????????????????69結(jié)論?????????????????????75參考
4、文獻(xiàn)???????????????????..75全文總結(jié)???????????????????..82附錄?????????????????????83萬(wàn)方數(shù)據(jù)文獻(xiàn)綜述:膠質(zhì)瘤的化療新進(jìn)展?????????????83后記????????????????????..103致謝????????????????????。.103個(gè)人小結(jié)???????????????????.104萬(wàn)方數(shù)據(jù)英文縮寫(xiě)AAAGTAIFBCRPCCCPCrELCSFEDMSODREGFRFASFBSGAPDHGBMGSHH
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7、poptosisproteins50%inhibitingconcentrationimmunohistochemistryLethalDose50lungresistance——relatedproteinmitogen—activatedproteinkinasesmultidrugresistance06一methylguanine—DNAmethltransferasemagneticresonancemultidrugresistance——associatedproteinsNatio
8、nalCancerInstitutepolyADP—ribosepolymerasephosphatebufferedsalineP—GlycoproteinPropidiumiodide】中文全名間變型星形細(xì)胞瘤06一烷基鳥(niǎo)嘌呤-DNA烷基轉(zhuǎn)移酶凋亡誘導(dǎo)因子乳腺癌耐藥相關(guān)蛋白碳酰氰基一對(duì)一氯苯腙聚氧乙烯蓖麻油羧基熒光素二醋酸鹽琥珀酰亞胺酯二甲基亞砜死亡受體表皮生長(zhǎng)因子受體自殺相關(guān)因子胎牛血清甘油醛一3一磷酸脫氫酶膠質(zhì)母細(xì)胞瘤谷胱甘肽高效能液相色譜凋亡抑制蛋白50%抑制濃度免疫組織