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1、BacterialResistanceinChinaMingguiWang,M.D.InstituteofAntibioticsHuashanHospital,FudanUniversityOutlineAntimicrobialResistanceandIt’sMechanismsGram-positivecocciStreptococcuspneumoniaeStaphylococcusspp.Gram-negativebacilliEnterobacteriaceaeEscherichiacoliKlebsiellaspp.Enteroba
2、cterspp.,etal.Non-fermentinggram-negativebacilli(non-fermenters)AntimicrobialResistanceinStreptococcuspneumoniaeHistoryofstudiesonantimicrobialresistanceonStreptococcuspneumoniae196719701978198019912001SpreadaroundtheworldFirstcaseofPRSPFirstcaseofMDRMechanismofPRSPRegionalpr
3、oblemGlobalproblemβ-lactams(penicillin)MacrolidesFluoroquinolonesPenicillinresistanceinS.pneumoniaeinChinainlate1990’YearRegionPopulationSourceNo.ofStrainsPNSSP(%)PISP(%)PRSP(%)96-99ShanghaiAdultsClinical68330ChildrenClinical60131301998ChildrenCarriage222141401998GuangzhouCli
4、nical10212120ChildrenCarriage151151501997*BejingClinical7914112ChildrenCarriage2441413199-004centersClinical55314122PNSSP,penicillinnon-susceptibleS.pneumoniae;PISP,penicillinintermediateS.pneumoniae;PRSP,penicillinresistantS.pneumoniae*AAC1998;42:2633PenicillinresistanceinS.
5、pneumoniaeinChinainearly2000’YearRegionPopulationSourceNo.ofStrainsPNSSP(%)PISP(%)PRSP(%)2001ShanghaiChildrenClinical1005549601-02BeijingShenyangClinical19243321100-023centersChildrenClinical8874034600-014centersChildrenClinical62441374PNSSP,penicillinnon-susceptibleS.pneumon
6、iae;PISP,penicillinintermediateS.pneumoniae;PRSP,penicillinresistantS.pneumoniaePenicillinresistanceinS.pneumoniaehasbeenincreasingmarkedlysince2000IncreasingtrendsofPenicillinresistanceinS.pneumoniaeinChinaShanghai100strainseachyearBeijingMorethan100strainseachyearClinicalst
7、rainsisolatedfromChildren’sHospitalReasonscausingtherapidincreasingofpenicillinresistanceTheincreasingconsumptionoforalpenicillinssuchasamoxicillinThespeadofresistantcoloninesDifferenceofpenicillinresistanceinS.pneumoniaeisolatedbetweenadultsandchildrenYearRegionPopulationSou
8、rceNo.ofStrainsPNSSP(%)PISP(%)PRSP(%)96-99ShanghaiAdultsClinical6833
