20種中藥及其復(fù)方抗真菌實(shí)驗(yàn)與臨床分析

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1、:大風(fēng)子、皂角、川椒、明磯、董香、地骨丿目的：測(cè)定單味中藥及不同復(fù)方抑真菌MIC,篩選抗真菌藥紗選擇合適的抗;冑中藥復(fù)方治療手足癬。方法：實(shí)驗(yàn)采用試管內(nèi)藥基法，通過(guò)單味中藥實(shí)驗(yàn)研究’（先出有效抗真菌藥物，結(jié)合中醫(yī)理論，組成不同復(fù)方，進(jìn)行實(shí)驗(yàn)研究。然后，將復(fù):龍用于臨床，進(jìn)行臨床療效評(píng)價(jià)。卬菌作用最強(qiáng)，對(duì)皮膚癬菌MIC在1.25%~2?5%之間。只有大風(fēng)子、川椒、苦參在丿■西濃度內(nèi)對(duì)白色念珠菌達(dá)到抑菌效果。通過(guò)不同治則組成的復(fù)方抑皮膚癬菌MIC彳_--一一…■_?播訂頭風(fēng)子、L625%?1.25%之間。對(duì)白色念珠菌也有一定的抑制作用，MIC在10%?20%之間。；正治療手足癬療效好于單獨(dú)應(yīng)

2、用殺蟲(chóng)藥，療效與1%特比蔡芬相當(dāng)笆角、川椒、明磯、霍香、地骨皮抑菌作用最強(qiáng)。通過(guò)不同治則組成的復(fù)方抑菌強(qiáng)丿勻明顯提髙。通過(guò)實(shí)驗(yàn)室篩選，結(jié)合辨證用藥組成復(fù)方治療手足癬療效最好。關(guān)鍵詞真斷）中藥；侯驗(yàn)研弦）臨床研究）、ClinicalandExperimentalStudyonantifungalEffectsofTwentyChineseHerbsandCompoundsSpeciality:dermatolotysurgeryofTCMAuthor:YuTenglktor:DuXixianAbstractObjective:ToexamineMICofthesingleChinesehe

3、rbandthecompoundsaselectappropriateanti-fiingaldrugsandselectappropriateanti-fungalcompoundtotreattiimanuumandtineapedis.Method:Withadoptingthetubediskapproach,theeffectanti-fungalherbsareselectedbyexperimentalstudyofasingleChineseherb.WcombiningthetheoryofTCM,differentcompoundsareformedandstudie

4、d.Thendifferentcompoundsareusedintheclinicalcases.Andtheclinicalcurativeeffectevaluated.Results:ManyherbsincludingHydnocarpusanthelminticaPierre>GleditsinensisLam、ZanthoxylumbungeanumMaxim、Alunite、Pogostemoncablin(Blan

5、astronglyinhibitoryeffectondermatophyte(MIC:1.25%?2.5%).TherenothingbutthreeherbsincludingHydnocarpusanthelminticaPierre.ZanthoxylibungeanumMaximandSophoraflavescensAit,thatinhibitthegrowthofCandalbicans.Chineseherbalcompoundsbasedonthedifferenttreatmentprincipalcaninhi■thegrowthofdermatophytetoa

6、certainextent(MIC:0.625%~1.25%),andatthesatimecaninhibitthegrowthofCandidaalbicans(MIC:10%~20%).Thereisasignificdifferencebetweenthetreatmentgrouponeandthetreatmentgrouptwo(P<0.05).Athereisnodifferencebetweenthetreatmentgrouponeandcontrolgroup(P>0.CConclusion:HydnocarpusanthelminticaPierre、Gledit

7、siasinensisLam%ZanthoxylibungeanumMaximaAlunite、Pogostemoncablin(Blanco)Bentli,andtherootofLyciichinenseMillxanstronglyinhibitthegrowthoffungus.Thecompoundsbasedondiffer淺部真菌病為一慢性傳染病，近年來(lái)，淺部真菌病發(fā)病率有增髙趨勢(shì)。手足癬:IIIIII良常見(jiàn)的淺部真菌