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1、臨床放射學(xué)雜志2013年第32卷第11期·1555·中樞神經(jīng)放射學(xué)進(jìn)行性核上性麻痹患者中腦形態(tài)的MRI研究馮結(jié)映,黃飚,楊萬群,王麗敏,張玉虎【摘要】目的探討MRI中腦形態(tài)測量在診斷進(jìn)行性核上性麻痹(PSP)的臨床價值及其與帕金森病(PD)的鑒別診斷。方法經(jīng)臨床確診的PSP患者l8例,分析其MRI的中腦形態(tài)影像學(xué)特征;并與年齡及性別相匹配的l8例PD患者和18名正常人對比。結(jié)果l8例PSP患者中14例可見“蜂鳥征”、10例見“牽牛花征”;PSP組中有17例表現(xiàn)為中腦平直或內(nèi)凹,而PD組中僅有3例呈內(nèi)凹型。PSP組的中腦/橋腦面積低于PD組和對照組;中腦/橋腦面
2、積之比<0.18提示PSP診斷。結(jié)論觀察中腦萎縮對PSP具有較高的診斷價值,并能與PD相鑒別?!娟P(guān)鍵詞】進(jìn)行性核上性麻痹帕金森病磁共振成像MorphometryMRIStudyoftheMidbraininPatientswiUlProgressiveSupranuclearPalsyFENGJieying,HUANGBiao,YANGWanqun,eta1.SouthenMedicalUniversity,Guangdong510515,P.R.China【Abstract】ObjectiveToevaluatethevalueofmorphometryMR
3、Iofthemidbrainindiagnosisofprogressivesupranu-clearpalsy(PSP)anddiferentialdiagnosisbetweenPSPandParkinson,sdisease(PD).Methods18patientswithPSP.18agematchedpatientswithPDand18normalcontrolsubjectswereenrolled.Theimagingcharacteristicsofthemidbraininpatientswereanalyzed.ResultsHummi
4、ngbirdsignswasseenin14patientswithPSPandmorninggloryflow—ersignswereseenin10patients.Thepresencesofabnormalsuperiorprofileofthemidbrainweredemonstratedin17of18patientswithPSP,whileonly3patientswithconcavemidbraininPDgroupandnoneincontrolgroup.Theaverageratio(areaofmidbrain/areaofpon
5、s)ofthepatientswithPSP(0.17)wassignificantlysmallerthanthatofthepatientswithPD(O.23)andthatincontrolgroup(O.23).Themidbrain/ponsratio<0.18suggestedthediagnosisofPSP,andthediag-nosticsensitivityandspecificityweDg72.2%and88.9%.respectively.ConclusionTheevaluationofmidbrainatrophyisuse
6、fulindiagnosisofpatientswithPSP.a(chǎn)ndwhichcanhelptodifferentiatePSPfromPD.【Keywords】ProgressivesupranuclearpalsyParkinsondiseaseMagneticresonanceimaging本研究為國家自然科學(xué)基金資助項目(編號:81271560)作者單位:510515廣州,南方醫(yī)科大學(xué)(馮結(jié)映);510080廣東省醫(yī)學(xué)科學(xué)院,廣東省人民醫(yī)院放射科(黃飚、楊萬群);神經(jīng)內(nèi)科(王麗敏、張玉虎);}通訊作者12LohlePN,VanMamemnH,Zwin
7、dermanKH,eta1.Onthepathogen-14沈紀(jì)芳,沈海林,丁乙.星形膠質(zhì)細(xì)胞瘤術(shù)后殘留或復(fù)發(fā)與放射esisofbraintumourcysts:avolume~cstudyoftumour,oedema性壞死的臨床及MRI表現(xiàn)特點分析.蘇州大學(xué)學(xué)報(醫(yī)學(xué)版),andcyst.Neuroradiology,2000,42:6392002,22:56113SchoeneggerK,ObemdorferS,WaschitB,eta1.PeritumoraledemaonMR/atinitialdiagnosis:anindependentprogn
8、osticfactorforclio—