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1、中國(guó)當(dāng)代醫(yī)藥2015年6月第22卷第17期·中西醫(yī)結(jié)合研究·米非司酮聯(lián)合甲氨蝶呤中藥保守治療異位妊娠的臨床效果分析鐘文芳許子花王潔黃益輝廣東省惠東縣第二人民院.廣東惠東516351【摘要】目的探討米非司酮聯(lián)合甲氨蝶呤中藥保守治療異位妊娠的臨床效果。方法選取本院2011年1月~2014年1月收治的109例異位妊娠患者作為研究對(duì)象。均為保守治療,辯證使用中藥并聯(lián)合米非司酮與甲氨蝶呤治療。根據(jù)血B—HCG水平不同將其分為A組(<1000IU/L)39例,B組(1000~2000IU/L)50例,c組(<20
2、00IU/L)20例。經(jīng)藥物治療后比較3組的治療效果及臨床癥狀改善情況。結(jié)果3組的陰道停止流血時(shí)間、腫塊消失時(shí)間、腹痛消失平均時(shí)間、血p—HCG轉(zhuǎn)陰時(shí)間比較,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。A組的陰道停止流血時(shí)間、腫塊消失時(shí)間、腹痛消失平均時(shí)間、血B—HCG轉(zhuǎn)陰時(shí)間顯著短于B、C組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。B組的陰道停止流血時(shí)間、腫塊消失時(shí)間、腹痛消失平均時(shí)間、血p—HCG轉(zhuǎn)陰時(shí)間顯著短于C組,差異有統(tǒng)計(jì)學(xué)意義(尸l<0.05)。3組的愈顯率比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(0.05)。結(jié)論米非司酮
3、聯(lián)合甲氨蝶呤和中藥對(duì)異位妊娠進(jìn)行保守治療效果顯著,可有效促進(jìn)胚胎機(jī)化、吸收,消除包塊,恢復(fù)血p—HCG水平。根據(jù)血p—HCG水平進(jìn)行治療,其水平越低治療效果越顯著?!娟P(guān)鍵詞】異位妊娠;保守治療;米非司酮;甲氨蝶呤;中藥【中圖分類號(hào)】R714.2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1674—4721(2015)06(b)一0155—03Clinicaleffectanalysisofmifepristone.methotrexatecombinedwithtradi-tionalChinesemedicinei
4、ntheconservativetreatmentofectopicpregnancyZHONGWen-fangXUZi—huaWANGeHUANGYi—huiTheSecondPeopleSHospitalofHuidongCountyinGuangdongProvince,Huidong516351,China[Abstract]ObjectiveToexploretheclinicaleffectofmifepristone,methotrexatecombinedwithtraditional
5、Chinesemedicineintheconservativetreatmentofectopicpregnancy.Methods109patientswithectopicpregnancyfromJan—uary2011toJanuary2014inourhospitalwereselectedasresearchobjects.Allpatientsweretreatedwithconservativetreatment,anddialecticalusetraditionalChinese
6、medicinewithmifepristoneandmethotrexatewasapplied.Accordhagtodifferentlevelofserum~-HCG,allpatientsweredividedintogroupA(n=39,lessthan1000IU/L),groupB(n=50,1000—2000IU/L)andgroupC(n=20,morethan2000IU/L).Afterdrugtherapy,thetherapeuticeffectandclinicalsy
7、mptomsimprovedconditionamongthreegroupswascompared.ResultsTherewassignificantdifferenceinthetimeofvaginalbleedingstopping,lumpdisappearing,abdominalpaindisappearing,andserum13-HCGconvertingtobenegativeamongthreegroups(P<0.05).Thetimeofvaginalbleedingsto
8、pping,lumpdisappearing,abdominalpaindisappearing,andsCrUB13-HCGconvertingtobenegativeingroupAwasshorterthanthatingroupBandgroupC,withsignificantdifference(Pl<0.05).Thetimeofvaginalbleedingstopping,lumpdisappearing,abdominalpaindi