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1、Chinese-GermanJClinOncolOctober2013,Vol.12,No.10,P498–P501DOI10.1007/s10330-013-1222-y雷替曲塞動脈灌注化療分析(威客yyhf5)梁軍,元龍陳,潘慧娟,錢鷹,徐丹,李敏無錫市惠山區(qū)人民醫(yī)院腫瘤科,郵編214187,中國無錫市惠山區(qū)AbstractObjective:Theaimofthisstudywastoanalysisraltitrexedbythesafetyandefficacyofintra-arterialinfusi
2、onchemotherapy.Methods:Forty-sevencasesindifferentpartsofcancerpatients,interventionalmethods,basedondigitalsubtractionangiography(DSA)prompt,raltitrexed-basedchemotherapy,thetumornourisharteryinfusionchemotherapy.Patientswithpostoperativechemotherapysideeffec
3、tsandcomplications,andefficacyassessments.Results:Forty-sevenpatients,2patientshadII–IIIdegreeofbonemarrowsuppression,theratewas4.26%,34casesofItoIIdegreegastrointestinalreactions,1caseofgradeIIIgastrointestinalreactions,theincidenceof2.13%,and1casemilddiarrhe
4、a.Idegreesormorechemotherapy-relatedadversereactionsdidnotoccurinthisgroupofpatients.Allpatientsreceivedatleast2timesarterialinfusionchemotherapy,completeremission(CR)3cases,partialremission(PR)11cases,stabledisease(SD)17cases,diseaseprogression(PD)6cases,tota
5、leffectiverateoftreatment87.23%.Conclusion:Raltitrexedforintra-arterialchemotherapyissafeandeffective.However,duetothesmallnumberofthisgroupofpatients,timeisshort,itssafety,efficacyandlong-termefficacyneedsfurtherobservationandvalidation.【摘要】目的:本研究的目的是分析由動脈灌注的
6、雷替曲塞化療方法安全性和有效性。方法:使用介入法,對47例癌癥患者的不同部位,在數(shù)字減影血管造影(DSA)輔助下,使用以雷替曲塞為藥物基礎(chǔ)的腫瘤動脈灌注入化療。患者術(shù)后化療的毒副作用和并發(fā)癥療效評估:四十七例患者中,2例出現(xiàn)Ⅱ?Ⅲ度骨髓抑制,發(fā)生率為4.26%,出現(xiàn)34例Ⅰ?Ⅱ度胃腸道反應,1例Ⅲ級胃腸道反應,發(fā)病率為%2.13,1例輕度腹瀉。在這組患者中沒有出現(xiàn)1度以上化療相關(guān)的不良反應。所有患者均接受至少2次動脈灌注化療,完全緩解(CR)3例,部分緩解(PR)11例,疾病穩(wěn)定(SD)17例,疾病惡化(PD)6例
7、,治療總有效率達87.23%。結(jié)論:雷替曲塞動脈灌注化療是安全有效的。然而,由于本組中病例少,時間短,其安全性,療效和遠期療效有待進一步觀察和驗證。Keywordsraltitrexed;transcatheterarterialchemo-infusion;security;validity關(guān)鍵詞雷替曲塞;導管動脈化療灌注;安全性;有效性Raltitrexedtothyminesynthetaseinhibitor,isquinazolinefolateanalogs,arecytotoxicdrugs,prim
8、arilyforthetreatmentofcolorectalcancer.Accordingtoforeignliterature,raltitrexedhasalsobeenusedinclinicaltreatmentofgastriccancer,-10-Chinese-GermanJClinOncolOctober2013,Vol.12,No.1