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1、Chinese-GermanJClinOncolOctober2013,Vol.12,No.10,P498–P501DOI10.1007/s10330-013-1222-y雷替曲塞動脈灌注化療分析(威客yyhf5)梁軍,元龍陳,潘慧娟,錢鷹,徐丹,李敏無錫市惠山區(qū)人民醫(yī)院腫瘤科,郵編214187,中國無錫市惠山區(qū)AbstractObjective:Theaimofthisstudywastoanalysisraltitrexedbythesafetyandefficacyofintra-arterial
2、infusionchemotherapy.Methods:Forty-sevencasesindifferentpartsofcancerpatients,interventionalmethods,basedondigitalsubtractionangiography(DSA)prompt,raltitrexed-basedchemotherapy,thetumornourisharteryinfusionchemotherapy.Patientswithpostoperativechemother
3、apysideeffectsandcomplications,andefficacyassessments.Results:Forty-sevenpatients,2patientshadII–IIIdegreeofbonemarrowsuppression,theratewas4.26%,34casesofItoIIdegreegastrointestinalreactions,1caseofgradeIIIgastrointestinalreactions,theincidenceof2.13%,a
4、nd1casemilddiarrhea.Idegreesormorechemotherapy-relatedadversereactionsdidnotoccurinthisgroupofpatients.Allpatientsreceivedatleast2timesarterialinfusionchemotherapy,completeremission(CR)3cases,partialremission(PR)11cases,stabledisease(SD)17cases,diseasepr
5、ogression(PD)6cases,totaleffectiverateoftreatment87.23%.Conclusion:Raltitrexedforintra-arterialchemotherapyissafeandeffective.However,duetothesmallnumberofthisgroupofpatients,timeisshort,itssafety,efficacyandlong-termefficacyneedsfurtherobservationandval
6、idation.【摘要】目的:本研究的目的是分析由動脈灌注的雷替曲塞化療方法安全性和有效性。方法:使用介入法,對47例癌癥患者的不同部位,在數(shù)字減影血管造影(DSA)輔助下,使用以雷替曲塞為藥物基礎(chǔ)的腫瘤動脈灌注入化療?;颊咝g(shù)后化療的毒副作用和并發(fā)癥療效評估:四十七例患者中,2例出現(xiàn)Ⅱ?Ⅲ度骨髓抑制,發(fā)生率為4.26%,出現(xiàn)34例Ⅰ?Ⅱ度胃腸道反應(yīng),1例Ⅲ級胃腸道反應(yīng),發(fā)病率為%2.13,1例輕度腹瀉。在這組患者中沒有出現(xiàn)1度以上化療相關(guān)的不良反應(yīng)。所有患者均接受至少2次動脈灌注化療,完全緩解(CR)3
7、例,部分緩解(PR)11例,疾病穩(wěn)定(SD)17例,疾病惡化(PD)6例,治療總有效率達87.23%。結(jié)論:雷替曲塞動脈灌注化療是安全有效的。然而,由于本組中病例少,時間短,其安全性,療效和遠期療效有待進一步觀察和驗證。Keywordsraltitrexed;transcatheterarterialchemo-infusion;security;validity關(guān)鍵詞雷替曲塞;導(dǎo)管動脈化療灌注;安全性;有效性Raltitrexedtothyminesynthetaseinhibitor,isquina
8、zolinefolateanalogs,arecytotoxicdrugs,primarilyforthetreatmentofcolorectalcancer.Accordingtoforeignliterature,raltitrexedhasalsobeenusedinclinicaltreatmentofgastriccancer,-10-Chinese-GermanJClinOncolOctober2013,Vol.12,No.1