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1、Chinese-GermanJClinOncolOctober2013,Vol.12,No.10,P498–P501DOI10.1007/s10330-013-1222-y雷替曲塞動(dòng)脈灌注化療分析（威客yyhf5）梁軍，元龍陳，潘慧娟，錢(qián)鷹，徐丹，李敏無(wú)錫市惠山區(qū)人民醫(yī)院腫瘤科，郵編214187，中國(guó)無(wú)錫市惠山區(qū)AbstractObjective:Theaimofthisstudywastoanalysisraltitrexedbythesafetyandefficacyofintra-arterialinfusion
2、chemotherapy.Methods:Forty-sevencasesindifferentpartsofcancerpatients,interventionalmethods,basedondigitalsubtractionangiography(DSA)prompt,raltitrexed-basedchemotherapy,thetumornourisharteryinfusionchemotherapy.Patientswithpostoperativechemotherapysideeffectsan
3、dcomplications,andefficacyassessments.Results:Forty-sevenpatients,2patientshadII–IIIdegreeofbonemarrowsuppression,theratewas4.26%,34casesofItoIIdegreegastrointestinalreactions,1caseofgradeIIIgastrointestinalreactions,theincidenceof2.13%,and1casemilddiarrhea.Ideg
4、reesormorechemotherapy-relatedadversereactionsdidnotoccurinthisgroupofpatients.Allpatientsreceivedatleast2timesarterialinfusionchemotherapy,completeremission(CR)3cases,partialremission(PR)11cases,stabledisease(SD)17cases,diseaseprogression(PD)6cases,totaleffecti
5、verateoftreatment87.23%.Conclusion:Raltitrexedforintra-arterialchemotherapyissafeandeffective.However,duetothesmallnumberofthisgroupofpatients,timeisshort,itssafety,efficacyandlong-termefficacyneedsfurtherobservationandvalidation.【摘要】目的：本研究的目的是分析由動(dòng)脈灌注的雷替曲塞化療方法安全
6、性和有效性。方法：使用介入法，對(duì)47例癌癥患者的不同部位，在數(shù)字減影血管造影（DSA）輔助下，使用以雷替曲塞為藥物基礎(chǔ)的腫瘤動(dòng)脈灌注入化療。患者術(shù)后化療的毒副作用和并發(fā)癥療效評(píng)估：四十七例患者中，2例出現(xiàn)Ⅱ?Ⅲ度骨髓抑制，發(fā)生率為4.26％，出現(xiàn)34例Ⅰ?Ⅱ度胃腸道反應(yīng)，1例Ⅲ級(jí)胃腸道反應(yīng)，發(fā)病率為％2.13，1例輕度腹瀉。在這組患者中沒(méi)有出現(xiàn)1度以上化療相關(guān)的不良反應(yīng)。所有患者均接受至少2次動(dòng)脈灌注化療，完全緩解（CR）3例，部分緩解（PR）11例，疾病穩(wěn)定（SD）17例，疾病惡化（PD）6例，治療總有效率達(dá)87.2
7、3％。結(jié)論：雷替曲塞動(dòng)脈灌注化療是安全有效的。然而，由于本組中病例少，時(shí)間短，其安全性，療效和遠(yuǎn)期療效有待進(jìn)一步觀察和驗(yàn)證。Keywordsraltitrexed;transcatheterarterialchemo-infusion;security;validity關(guān)鍵詞雷替曲塞;導(dǎo)管動(dòng)脈化療灌注;安全性;有效性Raltitrexedtothyminesynthetaseinhibitor,isquinazolinefolateanalogs,arecytotoxicdrugs,primarilyforthetre
8、atmentofcolorectalcancer.Accordingtoforeignliterature,raltitrexedhasalsobeenusedinclinicaltreatmentofgastriccancer,-10-Chinese-GermanJClinOncolOctober2013,Vol.12,No.1
