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1、第16卷第8期中國普通外科雜志Vol.16No.82007年8月ChineseJournalofGeneralSurgeryAug.2007文章編號:1005-6947(2007)08-073503·肝移植專題研究·重型肝炎急性肝衰竭肝移植手術(shù)指征探討李杰群,齊海智,賀志軍,胡偉,司中州,李一寧(中南大學湘雅二醫(yī)院普外器官移植中心,湖南長沙410011)摘要:目的總結(jié)重型肝炎實施急診肝移植的經(jīng)驗,探討其手術(shù)指征。方法回顧性分析34例擬行急診肝移植治療的重型肝炎并急性肝衰竭患者的臨床資料,其中11例實施急診肝移植手術(shù)。結(jié)果34例患者中,14例在等待供體中死亡,另9例在轉(zhuǎn)入我科時已
2、喪失手術(shù)機會,于3d內(nèi)死亡。11例急診肝移植均采用改良背馱式肝移植,其中1例術(shù)后7d死于肺部感染、急性呼吸窘迫綜合征(ARDS),1例術(shù)后20d死于原發(fā)性移植肝功能不良合并腎功能衰竭,其他9例術(shù)后均恢復順利。隨訪6~29個月,1例于術(shù)后12個月死于慢性排斥反應(yīng),余8例情況良好。結(jié)論急診肝移植是治療重型肝炎合并急性肝功能衰竭移植的有效方法,其指征為:(1)Ⅱ級及Ⅱ級以上的進行性腦?。唬ǎ玻校匝娱L15s以上(或凝血酶原活動度<30%);(3)血清TBIL!300μmol/L(17.5mg/dl)或TBIL進行性升高(每天>17.1μmol/L)。[中國普通外科雜志,2007,16(
3、8):735-737]關(guān)鍵詞:肝移植;肝功能衰竭,急性/外科學;手術(shù)指征中圖分類號:R617文獻標識碼:ATheoperativeindicationsfororthotopiclivertransplantationinacuteliverfailurecausedbyseverehepatitisLIJiequn,QIHaizhi,HEZhijun,HUWei,SIZhongzhou,LIYining(TheOrganTransplantationCenterofXiangyaSecondHospital,CentralSouthUniversity,Changsh
4、a410011,China)Abstract:ObjectiveTosummarizetheexperienceofemergencyorthotopiclivertransplantation(EOLT)forseverehepatitis,anddiscusstheoperativeindications.MethodsTheclinicaldataof34patientswithseverehepatitisandacuteliverfailure.whowerecandidatesforlivertransplantationwasretrospectivereviewe
5、d.ResultsAmongthe34patients,11ofthemunderwentlivertransplantation,14ofthemdiedwhilewaitingfordonorliverand9caseslostthechanceofundergoingtransplantation.Inthe11caseswithlivertransplatation,onecasediedofpulmonaryinfectionandacuterespiratorydistresssyndrome(ARDS)onpostoperativeday7,onecasediedo
6、fprimarypoorgraftfunctionandrenalfailureonpostoperativeday20,andtheother9casesmadeagoodrecovery.Atfollowupof6-29months,1casediedofchronicrejection12monthsafteroperation.ConclusionsEmergencylivertransplantationiseffectivetreatmentforacuteliverfailurecausedbyseverehepatitis.Theindicationsforthe
7、operationare:(1)StageⅡorhigherdegreeofencephalopathy:(2)prolongationofPT>15s;(3)SerumTBIL>300μmol/L(17.5mg/dl)orprogressivedailyincreaseofTBIL(>17.1μmol/L).[ChineseJournalofGeneralSurgery,2007,16(8):735-737]Keywords:LiverTransplantation;Liver