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1、分類號:R71學(xué)校代碼:10392學(xué)科專業(yè)代碼:115110學(xué)號:200901175福建醫(yī)科大學(xué)碩士研究生畢業(yè)論文中西醫(yī)結(jié)合治療卵巢早衰臨床療效的Meta分析Meta-AnalysisofprematureovarianfailuretreatedcombinedChineseandwesternmedicines學(xué)位類型:臨床醫(yī)學(xué)碩士所在學(xué)院:協(xié)和臨床學(xué)院研究生:胡傳莉?qū)W科、專業(yè):婦產(chǎn)科學(xué)導(dǎo)師:項雙衛(wèi)副教授研究起止日期:2011年3月至2012年3月答辯日期:2012年6月7日二○一二年六月1萬方數(shù)據(jù)2萬方數(shù)據(jù)目錄英漢縮略語名詞對照·················
2、··················2中文摘要··············································3英文摘要··············································4論文正文:中西醫(yī)結(jié)合治療卵巢早衰臨床療效的Meta分析前言··················································5材料與方法···········································5結(jié)果···································
3、············7討論·················································15全文總結(jié)·············································17參考文獻(xiàn)·············································18綜述··················································19致謝··················································263萬方數(shù)據(jù)英漢縮略語名
4、詞對照英文縮寫英文全稱中文全稱POFprematureovaryfailure卵巢早衰FSHfolliclestimulatinghormone卵泡刺激素LHluteinizinghormone黃體生成素E2estrogen雌二醇HRThormonereplacementtherapy激素替代治療FSHRfolliclestimulatinghormonereceptor卵泡刺激素受體LHRluteinizinghormone黃體生成素受體AOABantiovarianantibodies抗卵巢抗體AZPABantizonapellucidantibodies透明帶抗
5、體OOABantiovoplasmantibodies卵漿抗體MG-ABanti-membranegranularcellantibody抗顆粒細(xì)胞抗體BMIbodymassindex體重指數(shù)MDmeandifference均數(shù)差RRrelativerisk相對危險度CIconfidenceinterval置信區(qū)間Ffixedeffectmodel固定效應(yīng)模型Rrandomeffectmodel隨機(jī)效應(yīng)模型RCTRandomizedControlledTrials隨機(jī)對照試驗CCTControlledClinicalTrial臨床對照試驗4萬方數(shù)據(jù)中西醫(yī)結(jié)合治療卵巢早
6、衰臨床療效的Meta分析摘要目的:系統(tǒng)評價中西醫(yī)結(jié)合治療卵巢早衰(POF)的臨床療效。方法:通過計算機(jī)檢索萬方數(shù)字知識平臺、中國期刊網(wǎng)(CNKI)、維普數(shù)據(jù)庫(VIP)、PubMed、EMCC、OVID、CochraneLibrary以及在CALIS學(xué)位論文庫、中國學(xué)位論文數(shù)據(jù)庫(CDDB)、中國優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫(CDMD),從1999年至2011年7月國內(nèi)外公開發(fā)表的有關(guān)中西醫(yī)結(jié)合治療與西醫(yī)激素替代治療(HRT)卵巢早衰臨床療效比較的有關(guān)文獻(xiàn)。按Cochrane系統(tǒng)評價方法,采用Revman4.2進(jìn)行Meta分析。結(jié)果:符合納入標(biāo)準(zhǔn)的文獻(xiàn)共10篇,包括6
7、50例患者。Meta分析顯示:合并OR=3.45,95%CI為[0.86,5.17]。合并效應(yīng)的檢驗Z=1.26(P<0.00001),差異有統(tǒng)計學(xué)意義。結(jié)論:分析結(jié)果顯示中西醫(yī)結(jié)合方案在治療卵巢早衰方面優(yōu)于單純西醫(yī)激素替代治療,對卵巢功能早衰患者血清激素水平和臨床癥狀均有改善作用,值得臨床推薦;但文章的隨機(jī)方法、分配隱藏、盲法及隨訪上有較大的不足,尤其是隨訪報道甚少,高質(zhì)量的研究文獻(xiàn)較少,提示今后在臨床研究的方法學(xué)上有待進(jìn)一步改善和提高。關(guān)鍵詞:卵巢早衰;中西醫(yī)結(jié)合治療;激素替代治療;Meta分析5萬方數(shù)據(jù)META-ANALYSISOFPREMAT