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1、甲潑尼龍治療兒童難治性肺炎支原體肺炎的臨床分析H的探?屮潑尼龍?jiān)趦和y治性肺炎支原體肺炎(RMPP)中的臨床應(yīng)用和療效。方法70例RMPP患兒,隨機(jī)分為對(duì)照組和觀察組,各35例。兩組均采用紅霉素抗感染治療,體溫穩(wěn)定48h后改阿奇霉素門服序貫治療,觀察組在抗感染的基礎(chǔ)上同時(shí)使用甲潑尼龍2mg/(kg?d)靜脈滴注治療。觀察兩組患兒體溫恢復(fù)正常時(shí)間、咳嗽緩解時(shí)間和肺部??音消失時(shí)間,對(duì)比治療前后兩組患兒中性粒細(xì)胞比值、C反應(yīng)蛋白和血清鐵蛋白改善情況。結(jié)果觀察組患兒體溫恢復(fù)正常時(shí)間、咳嗽消失時(shí)間和肺部??音消失時(shí)間分別為(3.7±1.7)、(5.7±2.1)
2、、(6.6±1.8)d,均短于對(duì)照組的(5.8±1.9)、(7.1±2.2)、(7.8±2.1)d,差異具有統(tǒng)計(jì)學(xué)意義(P〈0.05)。治療后,兩組患兒中性粒細(xì)胞比值、C反應(yīng)蛋白、血清鐵蛋白等炎癥相關(guān)指標(biāo)均較治療前改善,且觀察組患兒改善程度優(yōu)于對(duì)照組,差異具有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論對(duì)于RMPP患兒,在使用大環(huán)內(nèi)酯類抗生素的基礎(chǔ)上同時(shí)給予甲潑尼龍,能顯著縮短癥狀和體征持續(xù)時(shí)間,改善炎性指標(biāo),加快患兒恢復(fù)。如有不愿意被轉(zhuǎn)載的情況,己【關(guān)鍵詞】難治性肺炎支原體肺炎;兒童;甲潑尼龍DOI:10.14163/j.cnki.11-5547/r.2017.
3、15.003ClinicalanalysisofmethylprednisoloneinthetreatmentofchildrenrefractorymycoplasmapneumoniaepneumoniaYUJie-ming,WANGXing,WUChun-yuan,etal.DepartmentofPediatrics,ShenzhenAffiliatedMaternalandChildHealthCareHospitalofSouthernMedicalUniversity,Shenzhen518028,China[Abstract]Obje
4、ctiveToinvestigateclinicalapplicationandcurativeeffectbymethylprednisoloneinthetreatmentofchildrenrefractorymycoplasmapneumoniaepneumonia(RMPP).MethodsAtotalof70RMPPchildrenpatientswererandomlydividedintocontrolgroupandobservationgroup,with35casesineachgroup.Bothgroupsreceiveder
5、ythromycinforanti-infectiontreatment,followedbyoraladministrationofazithromycinassequentialtherapyafter48hwithstablebodytemperature.Theobservationgroupreceivedadditionalmethylprednisoloneby2mg/(kg?d)throughintravenousdripfortreatment.Observationwasmadeonbodytemperaturerecoveryti
6、me,coughremissiontimeandlungraledisappearancetimeinthetwogroups.Comparisonwasmadeonimprovementsofneutrophilratio,C一reactiveproteinandserumferritinbetweenthetwogroupsbeforeandaftertreatment.ResultsTheobservationgrouphadbodytemperaturerecoverytime,coughremissiontimeandlungraledisa
7、ppearancetimerespectivelyas(3.7±1.7),(5.7±2.1)and(6.6±1.8)d,whichwereallshorterthan(5.8±1.9),(7.1±2.2)and(7.8±2.1)dinthecontrolgroup,andtheirdifferencehadstatisticalsignificance(P〈0.05).Aftertreatment,bothgroupshadimprovementsofneutrophilratio,C一reactiveproteinandserumferritin,a
8、ndtheobservationgrouphadbetterimprovementdegree